孕足月正常血压孕妇血清尿酸水平与新生儿出生体重的相关性OA北大核心CSTPCD
Relationship between serum uric acid levels in normotensive pregnant women at full-term of pregnancy and birth weight of newborns
目的 探讨孕足月正常血压孕妇血清尿酸水平与新生儿出生体重的相关性.方法 分层随机抽取2012年1月至2022年12月期间中国医科大学附属盛京医院产科病房1200例足月分娩且血压正常的孕妇作为研究对象.根据分娩时新生儿体重将孕妇分为适于胎龄儿(AGA)组(n=600)、大于胎龄儿(LGA)组(n=300)、小于胎龄儿(SGA)组(n=300).收集3组患者各项临床指标并比较,采用logistic回归分析新生儿出生体重的影响因素.结果 LGA组、SGA组孕妇血尿酸分别为336(269～388)μmol/L和377(297～431)μmol/L,远高于AGA组[288(243～350)μmol/L],差异均有统计学意义(均P<0.001).将孕妇血清尿酸水平与LGA、SGA发生情况纳入多因素logistic回归分析,结果显示,LGA(孕妇血清尿酸水平每增加10μmol/L,调整后OR=1.040,95%CI:1.020～1.060)和SGA(孕妇血清尿酸水平每增加10μmol/L,调整后OR=1.072,95%CI:1.049～1.095)发生风险随尿酸水平增加而升高.LGA组新生儿出生体重百分位数与孕妇尿酸水平呈正相关(r=0.108,P<0.05);SGA组新生儿出生体重百分位数与孕妇尿酸水平呈负相关(r=-0.224,P<0.01).限制性立方样条回归分析显示,孕妇尿酸水平与新生儿出生体重呈现近似"U"形关系,新生儿出生体重在3000g时,母体尿酸水平最低.结论 孕足月血压正常孕妇血清尿酸水平是影响新生儿出生体重的独立危险因素.孕足月血压正常孕妇的血清尿酸水平与新生儿出生体重密切相关,其中LGA组呈正相关,SGA组呈负相关.
Objective To investigate the relationship between serum uric acid levels of full-term pregnant women with normal blood pressure and the birth weight of their newborns.Methods A total of 1200 pregnant women in the obstetrics ward of Shengjing Hospital of China Medical University were randomly selected by stratification for the study from January 2012 to December 2022.These women had full-term delive-ries and a normal blood pressure.According to the weight of neonates at delivery,they were divided into groups as follows:appropriate for gestational age(AGA,n=600),large for gestational age(LGA,n=300),and small for gestational age(SGA,n=300).Clinical data of the patients was collected for a retrospective study.Nonparametric tests were used to compare the differences in each group,and logistic regression was used to analyze the factors influencing neonatal birth weight.Results The maternal serum uric acid values in the LGA and SGA groups were 336(269-388)μmol/L and 377(297-431)μmol/L,respectively-much higher than that of the AGA group[288(243-350)μmol/L,P<0.001].Multivariate logistic regression analysis showed that the risk of occurrence for LGA(for every 10 μmol/L increase in the blood uric acid level of pregnant women,the adjusted OR=1.040,95%CI:1.020-1.060)and SGA(for every 10 μmol/L increase,the adjusted OR=1.072,95%CI:1.049-1.095)increased with the level of uric acid in the patients.The birth weight percentile of neonates in the LGA group was positively correlated with uric acid levels(r=0.108,P<0.05),while in the SGA group it was negatively correlated with uric acid levels(r=-0.224,P<0.01).Restrictive cubic spline regression analysis showed that the rela-tionship between maternal uric acid levels and newborn birth weight was similar to a"U"shape.When newborn birth weight was around 3000 g,maternal uric acid level was the lowest.Conclusion Serum uric acid level of full-term pregnant women with normal blood pres-sure is an independent risk factor for neonatal birth weight.Serum uric acid level of full-term pregnant women with normal blood pressure is closely associated to neonatal birth weight,and shows a positive correlation in the LGA group and negative correlation in the SGA group.
范悦;王珺;王晓明
中国医科大学附属盛京医院妇产科,沈阳 110004
临床医学
孕妇尿酸新生儿出生体重相关性
pregnant womanuric acidneonatal birth weightrelationship
《中国医科大学学报》 2024 (005)
427-433,438 / 8
辽宁省应用基础研究计划联合计划(2022020796-JH2/1015);吴阶平医学基金会临床科研专项资助基金(320.6750.2022-06-12)
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