中国药物评价2024，Vol.41Issue(2)：141-147,7.
响应面优化提取新鲜沙棘果中异鼠李素及其两性聚合物结构修饰
Response Surface Methodology Extraction of Isorhamnetin from Fresh Seabuckthorn and Design of Isorhamnetin Zwitterionic Polymers
摘要
Abstract
Objective:To establish a response surface optimization method for extracting isorhamnetin from fresh seabuckthorn fruits,and modify isorhamnetin with a high molecular amphoteric polymer.Methods:Design Expert 8.0.6 software and Box Behnken optimiza-tion were used to extract isorhamnetin from fresh seabuckthorn fruit,and the prepared isorhamnetin was self-assembled into an amphoteric polymer.Results:The optimized extraction temperature is 75 ℃,extraction time is 60 minutes,and the amount of hydrochloric acid added to 100g of fresh seabuckthorn fruit is 35 mL;The use of self-assembly mode to produce isothamnetin amphoteric polymer has complete reac-tion and good solubility.Conclusion:The response surface method is stable and feasible,and can be used to optimize the process of isorh-amnetin in fresh seabuckthorn fruit;The self-assembly mode is feasible for the structural modification of isothamnetin amphoteric polymers.关键词
响应面优化/新鲜沙棘果/异鼠李素/两性聚合物Key words
Response Surface Methodology/Fresh Seabuckthorn/Isorhamnetin/Zwitterionic Polymers分类
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赵磊,丁雪,孙艳杰,马金刚,孟军,姜大成,昝珂,杨铭..响应面优化提取新鲜沙棘果中异鼠李素及其两性聚合物结构修饰[J].中国药物评价,2024,41(2):141-147,7.基金项目
吉林省中药材标准,项目名称:新鲜沙棘果(JLYC-2021-024) （JLYC-2021-024）
吉林省发改委产业技术研究与开发项目(No.2020C037-3) （No.2020C037-3）
吉林省道地药材实体标本库和数字化信息平台建设 （）
