中国药物评价2024，Vol.41Issue(2)：148-154,7.
基于网络药理学探讨温阳散寒活血方治疗狭窄性腱鞘炎的作用机理
Mechanism of Wenyang Sanhan Decoction in Treating Stenosing Tenosynovitis Based on Network Pharmacology
摘要
Abstract
Objective:To explore the therapeutic mechanism of Wenyang Sanhan Decoction on stenosing tenosynovitis using method of network pharmacology.Methods:The active components and potential target genes of Wenyang Sanhan Decoction were searched and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).These genes were mapped with the tenosynovitis related genes obtained by Genecards and OMIM database.The gene names of the targets were sorted out and stand-ardized based on the Uniprot data platform,and String 11.5 database and Cytoscape 3.9.1 software were used to construct the protein-pro-tein interaction(PPI)network and the active ingredient-core target network.Then,gene ontology(GO)and Kyoto Encyclopedia of Gene and Genome(KEGG)enrichment analysis of core target genes were carried out by using DAVID 6.8 platform.Results:A total of 41 ef-fective chemical components and 96 action targets were screened out.The core active components of Wenyang Sanhan Decoction in the treatment of tenosynovitis are β-sitosterol,quercetin,kaempferol,myricetin and so on,and core target genes were mainly involved in IL6,VEGFA and so on.48 molecular functions were obtained by GO functional enrichment analysis,and 47 signal pathways were ob-tained by KEGG enrichment analysis,of which TNF signal pathway was the most closely related.Conclusion:Wenyang Sanhan Decoction can inhibit inflammation through multiple targets and pathways,so as to achieve the purpose of treating tenosynovitis.关键词
腱鞘炎/网络药理学/抗炎/免疫调节/作用机制Key words
Tenosynovitis/Network pharmacology/Anti-inflammatory/Immune regulation/Mechanism分类
医药卫生引用本文复制引用
赵丽萍,王潮虹,梁博文,李波,罗静月,王桂荣,杨新婷..基于网络药理学探讨温阳散寒活血方治疗狭窄性腱鞘炎的作用机理[J].中国药物评价,2024,41(2):148-154,7.基金项目
北京市属医院科研培育计划项目(课题号:PZ2021029) （课题号:PZ2021029）
