中国药业2024，Vol.33Issue(11)：128,后插1-后插8,9.DOI:10.3969/j.issn.1006-4931.2024.11.029
维生素K治疗神经退行性疾病的分子机制与临床研究进展
Molecular Mechanism and Clinical Research Progress of Vitamin K in the Treatment of Neurodegenerative Diseases
摘要
Abstract
Objective To summarize the molecular mechanism and clinical research progress of vitamin K in the treatment of neurodegenerative diseases.Methods Literature analysis method was used to search literature related to vitamin K in the treatment of neurodegenerative diseases in the PubMed and CNKI databases from their inception to February 2024.The molecular mechanism of vitamin K in the treatment of neurodegenerative diseases was sorted out in terms of protein misfolding,mitochondrial dysfunction,oxidative stress,neuroinflammation,and ferroptosis.Results and Conclusion Vitamin K can improve mitochondrial function,reduce the incidence of oxidative stress,neuroinflammation,and ferroptosis,and reverse the pathological process of neurodegenerative diseases in cells or animal models by affecting the regulation of protein aggregation and autophagy.关键词
神经退行性疾病/维生素K/神经炎症/线粒体功能/蛋白聚集/自噬/氧化应激/铁死亡Key words
neurodegenerative diseases/vitamin K/neuroinflammation/mitochondrial function/protein aggregation/autophagy/oxidative stress/ferroptosis分类
医药卫生引用本文复制引用
邓靖,虞燕霞..维生素K治疗神经退行性疾病的分子机制与临床研究进展[J].中国药业,2024,33(11):128,后插1-后插8,9.基金项目
江苏省苏州市姑苏卫生人才计划培养项目[GSWS2020062]. （）
