中国中医药图书情报杂志2024，Vol.48Issue(4)：262-267,6.DOI:10.3969/j.issn.2095-5707.202309004
中药及其有效成分防治绝经后骨质疏松症机制研究进展
Research Progress in the Mechanism of Chinese Materia Medica and Its Active Components for the Treatment of Postmenopausal Osteoporosis
摘要
Abstract
Postmenopausal osteoporosis(PMOP)is one of the diseases caused by metabolic disorders of the skeletal system in postmenopausal women,which is prone to fracture during the onset of the disease and is characterized by a long treatment period,side effects of the first-line therapeutic drugs,prolonged and difficult to recover,and a serious decline in the quality of life,etc.Clinical manifestations of PMOP are mainly pains of the lower back and multiple joints of the limbs,occasionally accompanied by deformity of the trunk,generalized fatigue,abdominal discomfort and other symptoms.This article mainly elaborated that Chinese materia medica and its active components can promote osteoblast differentiation and osteogenic effects by regulating signaling pathways and activating the expression of key protein molecules in related signaling pathways,correct iron overload,regulate the intestinal flora,and play the effect of oestrogen to reverse the destruction of bone microstructure,improve bone mineral density,and balance the homeostasis,so as to achieve the improvement of bone metabolism and immunity,and then play a role in the treatment of PMOP,which could provide a reference for further research on the mechanism of PMOP treatment by Chinese materia medica and its active components.关键词
绝经后骨质疏松症/中药/有效成分/机制研究/综述Key words
PMOP/Chinese materia medica/active components/mechanism study/review分类
医药卫生引用本文复制引用
朱康,李宏键,陈会仙,向俊宜,保超宇,卢钰,尹本敬,李具宝..中药及其有效成分防治绝经后骨质疏松症机制研究进展[J].中国中医药图书情报杂志,2024,48(4):262-267,6.基金项目
国家自然科学基金地区科学基金(81860862) （81860862）
国家中医药管理局青年岐黄学者培养项目(2022年) （2022年）
云南省科技厅中青年学术和技术带头人后备人才及省级技术创新培养对象(2019年) （2019年）
云南省卫生健康委高层次中医药人才培养对象(2021年) （2021年）
