中国卒中杂志2024，Vol.19Issue(5)：573-578,6.DOI:10.3969/j.issn.1673-5765.2024.05.013
替罗非班联合机械取栓治疗急性缺血性卒中的研究进展
Research Progress of Tirofiban Combined with Mechanical Thrombectomy in the Treatment of Acute Ischemic Stroke
摘要
Abstract
In acute ischemic stroke patients with large vessel occlusion,mechanical thrombectomy can improve the hemodynamic status and clinical symptoms within the effective time,but mechanical thrombectomy is often associated with vascular re-occlusion,which affects the prognosis of patients.Platelet glycoprotein Ⅱb/Ⅲa(GPⅡb/Ⅲa)receptor antagonists prevent vascular re-occlusion by inhibiting the last common pathway of platelet aggregation.At present,the effects of GPⅡb/Ⅲa receptor antagonists on the clinical outcome during the perioperative period of mechanical thrombectomy in ischemic stroke remain controversial.This paper reviewd the efficacy and safety of tirofiban,a GPⅡb/Ⅲa receptor antagonist,in the treatment of vascular re-occlusion after mechanical thrombectomy in acute ischemic stroke.It was found that tirofiban combined with mechanical thrombectomy was safe for the treatment of acute ischemic stroke,but its therapeutic effectiveness still needs to be confirmed by standardized clinical research evidence.关键词
急性缺血性卒中/机械取栓/替罗非班/有效性/安全性Key words
Acute ischemic stroke/Mechanical thrombectomy/Tirofiban/Efficacy/Safety分类
医药卫生引用本文复制引用
郑国民,梁志刚,张振..替罗非班联合机械取栓治疗急性缺血性卒中的研究进展[J].中国卒中杂志,2024,19(5):573-578,6.基金项目
山东省医药卫生科技项目(202303070650)烟台市科技计划项目(2018SFGY092 （202303070650）
2021YD033) （）
