中华灾害救援医学2024，Vol.11Issue(3)：260-262,270,4.DOI:10.13919/j.issn.2095-6274.ZHJY202404031
卵巢癌新辅助化疗后血清CA125变化及CT检查对肿瘤细胞减灭术疗效的预测价值
Changes in Erum CA125 after Neoadjuvant Chemotherapy for Ovarian Cancer and the Predictive Value of CT Examination for the Efficacy of Cytoreductive Surgery
摘要
Abstract
Objective To evaluate the efficacy of using CA125 levels and CT scans to predict the efficacy of neoadjuvant chemotherapy combined with tumor cell reduction surgery in ovarian cancer patients.Methods patients diagnosed with epithelial ovarian cancer through pathological examination at Tengzhou Central People's Hospital from July 2021 to July 2023 were selected as the study subjects.All patients underwent neoadjuvant chemotherapy with platinum and paclitaxel before undergoing tumor cell reduction surgery.We analyze the general information of patients,the relationship between CA125 levels and satisfaction with tumor cell reduction surgery,chemotherapy efficacy,Jonathan's score on preoperative CT examination,and satisfaction with tumor cell reduction surgery.Results Comparingthe preoperative serum CA125≤45U/ml groupwiththe preoperative serum CA125＞45U/ml group,there was a significant difference in satisfaction with tumor cell reduction surgery between the two groups(P=0.001);There was a significant difference in satisfaction with tumor cell reduction surgery between the two groups,when we comparedthe preoperative serum CA125≤500U/ml groupwiththe preoperative serum CA125＞500U/ml group(P=0.005);There was a significant difference in satisfaction with tumor cell reduction surgery between the two groups,when we comparedthe decrease of≥80％in serum CA125 after surgery group and the decrease of＜80％in serum CA125 after surgery group(P=0.007);There was no significant difference in satisfaction with tumor cell reduction surgery between the two groups,when we compared the decrease of ≥ 50％in serum CA125 after surgery group and the decrease of＜50％in serum CA125 after surgery group(P=0.253).After 3 cycles of chemotherapy,there were 0 CR patients(0.00％),35 PR patients(51.47％),27 SD patients(39.71％),and 6 PD patients(8.82％).48 patients in the preoperative Jonathan score＜3 groups were satisfied with tumor cell reduction surgery,with a satisfaction rate of 96.00％.In the preoperative Jonathan score ≥ 3 groups,6 patients were satisfied with tumor cell reduction surgery,with a satisfaction rate of 33.33％,and the difference was statistically significant(P＜0.001).Conclusion Serum CA125 changes and CT examination can serve as predictive tools for the efficacy of tumor cell reduction in ovarian cancer patients,in order to provide reference for the selection of surgical timing for patients.关键词
卵巢肿瘤/肿瘤治疗方案/体层摄影扫描仪,X线计算机Key words
ovarian neoplasms/antineoplastic protocols/tomography scanners,X-ray computed分类
医药卫生引用本文复制引用
田翔宇,牛家成,姚淑娟,崔秀娟,王稳..卵巢癌新辅助化疗后血清CA125变化及CT检查对肿瘤细胞减灭术疗效的预测价值[J].中华灾害救援医学,2024,11(3):260-262,270,4.基金项目
山东省医药卫生科技发展计划项目(2018WSA04019) （2018WSA04019）
