摘要
Abstract
Objective To investigate the diagnostic effect of direct anti-human globulin test,free antibody test,and antibody release test for neonatal hemolytic disease.Methods Blood samples of 904 neonates with hyperbilirubinemia were selected from Xiamen Fifth Hospital from January 1,2020 to July 17,2023.Direct anti-human globulin test(anti-human globulin group),free antibody test(free antibody group),and antibody release test(antibody release group)were performed to compare the differences in detection results and explore diagnostic sensitivity.Results There was no significant difference in positive detection rate and negative detection rate among the three groups(P＞0.05).There was no significant difference in the positive detection rate of type A and type B among the three groups(P＞0.05).The diagnosis rate,specificity,and positive prediction of free antibody group were higher than those of the other two groups(P＜0.05).There was no significant difference in sensitivity and negative prediction among the three groups(P＞0.05).The results of direct anti-human globulin,free antibody,and antibody release test were consistent(Kappa=0.798,P＜0.05).Conclusion Direct antiglobulin test,free antibody test,and antibody release test are valuable in the diagnosis of hemolytic disease of newborn.In order to improve the clinical diagnosis rate of hemolytic disease of newborn,we should combine three kinds of examination methods.关键词
贫血,溶血性,先天性/高胆红素血症,新生儿/诊断Key words
anemia,hemolytic,aAutoimmune/hyperbilirubinemia,neonatal/diagnosis分类
医药卫生
