中南民族大学学报（自然科学版）2024，Vol.43Issue(4)：468-473,6.DOI:10.20056/j.cnki.ZNMDZK.20240406
光甘草定烟酰胺纳米乳的制剂评价与透皮吸收
Preparation evaluation and transdermal absorption of nanoemulsion loading glabridin and nicotinamide
摘要
Abstract
To improve the transdermal absorption properties of glabridin and nicotinamide,nano-emulsions(HPH-NE and HSSU-NE)were prepared by two high energy emulsification methods,and their morphology,particle size,Zeta potential,stability and skin permeability were investigated.The results showed that the two nanoemulsions were regular spherical without aggregation,their average particle size was respectively 51.60 nm and 42.98 nm,and the Zeta potential was-50.44 mV and-68.50 mV,respectively.HPH-NE and HSSU-NE had good stability under the conditions of centrifugation,storage and accelerated test.The nano-emulsion prepared by the two methods has better skin permeability than the ordinary emulsion,the average penetration rate of glabridin is increased by 3-5 times,and the average permeability of nicotinamide is increased by 1.6-2.6 times,which lays a solid foundation for the nano-preparation and cosmetics development of glabridin.关键词
纳米乳/高压均质法/高速剪切超声法/光甘草定/烟酰胺/稳定性/透皮吸收Key words
nanoemulsion/high pressure homogenization method/high speed shear ultrasonic method/glabridin/nicotinamide/stability/transdermal absorption分类
医药卫生引用本文复制引用
赵海燕,陆金玲,鲁妍,黄雨洁,王少兵..光甘草定烟酰胺纳米乳的制剂评价与透皮吸收[J].中南民族大学学报（自然科学版）,2024,43(4):468-473,6.基金项目
中央高校基本科研业务费专项资金资助项目(CZD20005) （CZD20005）
