中山大学学报（医学科学版）2024，Vol.45Issue(3)：344-353,10.
髓系细胞触发受体2在阿尔茨海默病中的作用
The Role of TREM2 Receptor in Alzheimer's Disease
摘要
Abstract
Alzheimer's disease(AD)is the most common form of senile dementia,and its pathogenesis is still un-clear.While β-amyloid(Aβ)is considered an important cause of AD,the pathological mechanism of Aβ inducing AD is subject to various controversies.Recent studies have shown that the myeloid cell trigger receptor(TREM2)plays an impor-tant role in the pathological process of AD,and it can not only serve as an important receptor for the internalization of Aβ but also become a biological diagnostic biomarker and therapeutic target.Hence,elucidating the structure and function of TREM2 will provide important ideas for the prevention and treatment of AD.This article will provide a systematic review of the structure of TREM2,its impact on microglial cell function,its pathological role in AD,and the current status of target-ed TREM2 therapy for AD.These summaries will provide valuable references for basic research on AD.关键词
阿尔茨海默病/髓系细胞触发受体/小胶质细胞/β淀粉样蛋白/细胞受体Key words
Alzheimer's disease/TREM2/microglia/β-amyloid/cell receptors分类
医药卫生引用本文复制引用
代玉婷,石镜明..髓系细胞触发受体2在阿尔茨海默病中的作用[J].中山大学学报（医学科学版）,2024,45(3):344-353,10.基金项目
国家自然科学基金(32160215,82360368) （32160215,82360368）
西藏民族大学"青年学人培育计划"资助项目(23MDX03) （23MDX03）
