中山大学学报（医学科学版）2024，Vol.45Issue(3)：354-360,7.
小檗碱保护糖尿病肾病肾脏作用机制研究进展
Research Progress on the Mechanisms of Berberine Protecting the Kidney in Diabetic Kidney Disease
摘要
Abstract
Diabetic kidney disease(DKD)is a chronic kidney disease caused by diabetes,influenced by genetic and environmental factors and their interaction.It is the primary cause of chronic kidney disease and end-stage renal disease.Recent studies have found,as a natural isoquinoline alkaloid,berberine(BBR)has hypoglycemic,hypolipidemic,antiox-idant,anti-inflammatory and anti-fibrotic properties,thus protects against kidney injury in DKD.The mechanisms of action of BBR may involve improving glucolipid metabolism,reducing oxidative stress,alleviating inflammatory responses,mitigat-ing renal fibrosis,regulating DNA methylation,promoting mitochondrial function and modulating the gut microbiota to enhance gut metabolism and clearance.This article systematically reviews the current status of research on the mechanisms of BBR in the treatment of DKD and provides reference for future clinical application of BBR in the treatment of DKD.关键词
小檗碱/糖尿病肾病/肾功能改善/作用机制/系统综述Key words
berberine(BBR)/diabetic kidney disease(DKD)/improved renal function/mechanisms of action/systematic review分类
医药卫生引用本文复制引用
曲柄衡,童晓鹏..小檗碱保护糖尿病肾病肾脏作用机制研究进展[J].中山大学学报（医学科学版）,2024,45(3):354-360,7.基金项目
国家自然科学基金(81560732) （81560732）
西藏自然科学基金(XZ202001ZR0068G) （XZ202001ZR0068G）
西藏民族大学青年学人培育计划(19MDX02) （19MDX02）
