小檗碱保护糖尿病肾病肾脏作用机制研究进展OA北大核心CSTPCD

Diabetic kidney disease(DKD)is a chronic kidney disease caused by diabetes,influenced by genetic and environmental factors and their interaction.It is the primary cause of chronic kidney disease and end-stage renal disease.Recent studies have found,as a natural isoquinoline alkaloid,berberine(BBR)has hypoglycemic,hypolipidemic,antiox-idant,anti-inflammatory and anti-fibrotic properties,thus protects against kidney injury in DKD.The mechanisms of action of BBR may involve improving glucolipid metabolism,reducing oxidative stress,alleviating inflammatory responses,mitigat-ing renal fibrosis,regulating DNA methylation,promoting mitochondrial function and modulating the gut microbiota to enhance gut metabolism and clearance.This article systematically reviews the current status of research on the mechanisms of BBR in the treatment of DKD and provides reference for future clinical application of BBR in the treatment of DKD.