中山大学学报（医学科学版）2024，Vol.45Issue(3)：370-376,7.
O连接N-乙酰葡萄糖胺糖基化修饰在神经退行性疾病中的研究进展
Research Progress on O-GLcNAc Glycosylation Modification in Neurodegenerative Diseases
摘要
Abstract
O-linked N-acetylglucosamine glycosylation(O-GlcNAcylation)is a protein post-translational protein formed by O-linked acetylglucosamine and serine/threonine residues on intracellular proteins.O-GlcNAc glycosylation modification is ubiquitous in the brain and is closely related to transcription,translation and protein homeostasis.O-GlcNAc glycosylation modification is involved in the occurrence and development of various neurological degenerative dis-eases,but its regulatory mechanism remains unclear.This paper reviews the relationship between O-GlcNAc glycosylation modification and neurological degenerative diseases.关键词
O连接N-乙酰葡萄糖胺糖基化/神经退行性变/O连接N-乙酰葡萄糖胺糖基转移酶/O连接N-乙酰葡萄糖胺糖苷酶/糖基化修饰Key words
O-GlcNAc glycosylation/neurodegeneration/OGT/OGA/glycosylation modification分类
医药卫生引用本文复制引用
余婷,刘海军..O连接N-乙酰葡萄糖胺糖基化修饰在神经退行性疾病中的研究进展[J].中山大学学报（医学科学版）,2024,45(3):370-376,7.基金项目
贵州省科技厅科技支撑计划项目(黔科合支撑[2020]4Y144号) （黔科合支撑[2020]4Y144号）
贵州省卫生和计划生育委员会科学技术基金项目(gzwjkj2018-1-001) （gzwjkj2018-1-001）
遵义医科大学"12345"未来人才培养计划"未来临床名医"项目(20211004) （20211004）
