中山大学学报（医学科学版）2024，Vol.45Issue(3)：383-392,10.
慢性鼻窦炎伴鼻息肉中MZB1的表达及其对局部免疫球蛋白表达的影响
Regulation of Local Immunoglobulin Expression by MZB1 in Chronic Rhinosinusitis with Nasal Polyps
摘要
Abstract
[Objective]The heightened expression of local immunoglobulins is a significant pathological characteristic of chronic rhinosinusitis with nasal polyps(CRSwNP),particularly in the Asian population.This study is centered on ex-ploring the association between MZB1 and the localized aggregation of immunoglobulins in Asian individuals with CRSwNP.[Methods]Nasal polyp tissues obtained from 40 CRSwNP patients and inferior turbinates from 6 healthy controls under-went examination for both mRNA and protein levels.The assessments were conducted using polymerase chain reaction,lu-minex,and immunohistochemical staining.Statistical analyses,including one-way Anova(ANOVA),independent sam-ples t-test,and Pearson's correlation analysis,were employed for comprehensive data evaluation.[Results]The mRNA ex-pression levels of MZB1(P<0.01)and HSP90B1(P<0.01)were significantly higher in type 2 CRSwNP patients com-pared with those in healthy controls.Immunohistochemical staining revealed a significant increase in MZB1 protein expres-sion in type 2 CRSwNP.MZB1 demonstrated correlation with the expression of immunoglobulin E in nasal polyp tissues(P<0.01,r=0.52).Additionally,MZB1correlated with the expression ofIL-5(P<0.05,r=0.4)and IL-13(P<0.05,r=0.44)in nasal polyp tissues.Furthermore,MZB1showed correlation with the number of eosinophils in nasal polyp tis-sues(P<0.05,r=0.72).[Conclusion]The expression of MZB1 is notably elevated in Asian CRSwNP,particularly in type 2 CRSwNP,when compared with controls.MZB1expression correlates significantly with high IgE expression and dis-ease severity in nasal polyp tissues.关键词
慢性鼻窦炎/慢性鼻窦炎伴鼻息肉/免疫球蛋白/边缘区B和B-1基因/IgEKey words
chronic rhinosinusitis/chronic rhinosinusitis with nasal polyps/immunoglobulin/MZB1/IgE分类
医药卫生引用本文复制引用
闫妍,许兆丰,黄嫣然..慢性鼻窦炎伴鼻息肉中MZB1的表达及其对局部免疫球蛋白表达的影响[J].中山大学学报（医学科学版）,2024,45(3):383-392,10.基金项目
国家自然科学基金(82301272) （82301272）
中国博士后科学基金(2022M723611) （2022M723611）
