中山大学学报（医学科学版）2024，Vol.45Issue(3)：429-437,9.
三明市妊娠期甲状腺激素参考范围的建立及分析
Establishment and Analysis of Reference Intervals for Thyroid Hormones in Pregnant Women from Sanming City
摘要
Abstract
[Objective]To establish the reference intervals of thyroid hormones in pregnant women from Sanming city and compare them with those from other areas in China.[Methods]The study recruited 605 pregnant women and 229 non-pregnant healthy women who visited Sanming First Hospital between March 29 and June 28,2023.Blood samples were se-quentially collected from the participants to determine the serum levels of thyroid stimulating hormone(TSH),free triiodo-thyronine(FT3)and free thyroxine(FT4).The reference intervals of thyroid hormones were established by using a percen-tile range of P2.5 to P97.5 and their changes in different periods of pregnancy were analyzed and compared with those from oth-er areas in China.[Results]There were significant differences in levels of TSH,FT4 and FT3 at different periods of pregnan-cy(all P<0.05).Compared with non-pregnant women,women in first trimester had significantly decreased levels of TSH and FT4,but similar level of FT3.Since the second trimester,TSH level displayed rising tendency,while FT3 and FT4 lev-els showed gradual decrease.The reference intervals of thyroid hormones in the first,second and third trimester of pregnan-cy in Sanming city were TSH(0.068,2.943)μU/mL,FT3(4.302,6.888)pmol/L,FT4(8.240,14.719)pmol/L;TSH(0.419,3.274)μU/mL,FT3(4.074,6.629)pmol/L,FT4(6.726,11.980)pmol/L;TSH(0.422,3.570)μU/mL,FT3(3.741,5.850)pmol/L,FT4(6.103,10.347)pmol/L,respectively.Significant differences were found in the reference in-tervals of thyroid hormones during pregnancy among different areas in China.[Conclusions]The levels of TSH,FT3,FT4 during pregnancy are different from those during non-pregnancy,and also significantly differ in different periods of preg-nancy.Reference intervals of thyroid hormones in pregnant women are affected by various factors such as geographic loca-tion,ethnicity and laboratory test method,etc.Therefore,establishing the population-specific reference intervals of thy-roid hormones will benefit for the diagnosis and treatment of thyroid disease in pregnant women from Sanming city.关键词
妊娠/甲状腺激素/参考范围/甲状腺疾病/妊娠结局/各省市/比较Key words
pregnancy/thyroid hormones/reference intervals/thyroid disease/pregnancy outcome/every province and city/analysis分类
医药卫生引用本文复制引用
林穗雯,姚敏蓉,吴芳燕,赵勇,林金梅,刘斌..三明市妊娠期甲状腺激素参考范围的建立及分析[J].中山大学学报（医学科学版）,2024,45(3):429-437,9.基金项目
国家重点研发项目(2021YFC2700703) （2021YFC2700703）
