中山大学学报（医学科学版）2024，Vol.45Issue(3)：438-445,8.
抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素分析
Analysis of Depression and Influencing Factors in HIV/AIDS Patients Receiving Antiviral Therapy
摘要
Abstract
[Objective]To investigate the depression status and its influencing factors in HIV/AIDS patients receiving antiviral therapy.[Methods]From July 2022 to September 2022,successive sampling method was used to recruit HIV/AIDS patients receiving antiviral therapy from antiviral treatment institutions in Nanjing,and they were instructed to fill out anonymous questionnaires.The questionnaire collected the basic information of patients,and depression,HIV stigma score and social support level were investigated by Patient Health Questionnaire-9(PHQ-9),Berger HIV stigma scale(BHSS)and Multidimensional Scale of Perceived Social Support(MSPSS).Multivariate Logistic regression was used to an-alyze the influencing factors of depression.[Results]A total of 1879 valid questionnaires were collected in this study,and the detection rate of depression was 50.1%.The results of multivariate logistic analysis showed that compared with patients with middle school or below,the risk of depression was lower for those with postgraduate or above[OR=0.534,95%CI(0.341,0.835),P=0.006].Compared with antiviral therapy duration<1 year,antiviral therapy duration for 1 to 5 years[OR=0.729,95%CI(0.536,0.991)],>5 to 10 years[OR=0.516,95%CI(0.379,0.702)],>10 years[OR=0.603,95%CI(0.375,0.969)]was associated with a lower risk of depression.High level of social support was a protective factor for depression in HIV/AIDS patients compared with middle and low level of social support[OR=0.430,95%CI(0.349,0.530),P<0.001].There was a higher risk of depression with side effects than without side effects[OR=2.260,95%CI(1.833,2.786),P<0.001].The higher the score on the HIV stigma scale,the higher the possibility of depression was.[Conclusion]The detection rate of depression of patients receiving antiviral therapy in Nanjing is high.After starting antivi-ral therapy,we should strengthen the monitoring of side effects and psychological status of patients,carry out psychologi-cal intervention,alleviate psychological problems,and improve the quality of life of patients receiving antiviral therapy.关键词
抗病毒治疗/艾滋病病毒感染者/艾滋病患者/抑郁/影响因素/回归分析Key words
antiviral therapy/HIV/AIDS patients/depression/influencing factor/logistic regression分类
医药卫生引用本文复制引用
袁欣,徐园园,朱正平,张敏,吴苏姝,王静文,王少康..抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素分析[J].中山大学学报（医学科学版）,2024,45(3):438-445,8.基金项目
南京市卫生科技发展专项资金(ZKX23059,YKK23192) （ZKX23059,YKK23192）
南京市疾控中心青年人才科研培育团队项目(NPY2307) （NPY2307）
江苏省社科应用研究精品工程课题(23SYC-007) （23SYC-007）
国家卫生健康委计划生育药具不良反应监测中心2023年度开放课题经费资助(JSHD202329) （JSHD202329）
江苏省科教能力提升工程专项经费资助(ZDXYS202210) （ZDXYS202210）
