中国现代医生2024，Vol.62Issue(14)：1-5,5.DOI:10.3969/j.issn.1673-9701.2024.14.001
浙江省健康人群胃蛋白酶原参考范围的建立
Establishment of reference intervals for pepsinogen in healthy populations in Zhejiang Province
摘要
Abstract
Objective To establish a reference interval for the pepsinogen(PG)Ⅰ,PGⅡ and PGⅠ/PGⅡ in healthy adult subjects in Zhejiang Province.Methods The data of 45 504 healthy adult subjects were collected,and the levels of serum PGⅠ and PG Ⅱ were detected by chemiluminescence microparticle immunoassay.The reference range of PGs were determined according to the CLSI-C28-A3 file.Results The median serum PGⅠ concentration in male was 132.62μg/L,PGⅡ concentration was 8.10μg/L,and PGⅠ/PGⅡ was 15.9.For females,they were 107.44μg/L,6.96μg/L and 15.0,respectively.PGI,PGⅡ concentration and PGⅠ/PGⅡ ratio were significantly higher in males than in females(P<0.001).The levels of PGⅠ and PGⅡ increased with age(P<0.001).Serum PGⅠ reference interval for male:59.79-234.97μg/L for 19-39 years old,63.33-294.62μg/L for 40-59 years old,64.25-333.61μg/L for≥60 years old,PGⅡ reference interval:3.33-22.60μg/L for 19-39 years of age,3.79-33.89μg/L for 40-59 years of age,4.15-42.08μg/L for≥60 years of age,PGⅠ/PGⅡ reference interval:those aged 19-39 years ranged from 7.3 to 31.4,those aged 40-59 years ranged from 5.8 to 30.9,and those aged≥60 years ranged from 3.9 to 30.7.The reference intervals of female PGⅠ were 48.79-215.68μg/L,52.10-276.01μg/L,and 64.34-317.20μg/L,respectively.The reference intervals of female PgⅡwere:2.87-23.93μg/L,3.41-33.31μg/L and 3.88-39.16μg/L,respectively.The reference intervals of of female PGⅠ/PGⅡ are 6.6-28.1,5.2-27.9 and 3.6-26.2.Conclusion This study determined the reference range of serum PGs deficiency in healthy subjects of different sex and age in Zhejiang Province.关键词
胃蛋白酶原/参考区间/化学发光微粒子免疫测定法/健康人群Key words
Pepsinogen/Reference intervals/Chemiluminescent microparticle immunoassay/Healthy population分类
医药卫生引用本文复制引用
徐秀湖,阳愿望,曹芳芳,解鸿翔,周斐斐..浙江省健康人群胃蛋白酶原参考范围的建立[J].中国现代医生,2024,62(14):1-5,5.基金项目
山东省自然科学基金项目(ZR2020MH116) （ZR2020MH116）
浙江省中医药科技计划项目(2023ZL009) （2023ZL009）
浙江省高校基本科研经费专项(KYYB202216) （KYYB202216）
浙江省教育厅一般科研项目(Y202146133) （Y202146133）
浙江省医药卫生科技计划项目(2021KY017,2022KY027) （2021KY017,2022KY027）
