中国中西医结合杂志2024，Vol.44Issue(5)：608-615,8.DOI:10.7661/j.cjim.20230411.073
基于脾和内质网—线粒体相关性探析助脾运化法治疗糖尿病
Correlation Between Pi and Endoplasmic Reticulum and Mitochondria:Discussion on Treatment of Diabetes Mellitus by Assisting Pi Transformation
摘要
Abstract
Diabetes is a common and frequently occurring clinical disease,closely linked to imbalances in energy metabolism.The endoplasmic reticulum(ER)and mitochondria,key organelles,play crucial roles in regulating various metabolic processes in the body.Imbalances in ER function and mitochondrial dysfunction can lead to insulin resistance and the accumulation of sugars and fats in the blood,subsequently causing disruptions in energy metabolism.This ultimately results in damage and apoptosis of pancreatic beta cells,thereby accelerating the onset and progression of diabetes.In Chinese medicine,the Pi is related to both the ER and mitochondria,with its primary function of transformation and transportation similar to the promotion of material and energy metabolism in modern medicine.When the Pi fails in its transformative functions,it leads to improper separation of the clear from the turbid,creating phlegm-dampness and stagnation in the middle burner,thus disrupting normal material and energy metabolism.Over time,a deficiency in Pi qi and the loss of essence disrupt the distribution,reducing power and weakening regulatory and metabolic actions.Assisting Pi transformation can support Pi qi and promote the flow of qi,the function of the Pi can be restored,and the balance of energy metabolism can be promoted.Therefore,based on the interaction between the ER and mitochondria,from two perspectives"Pi earth stagnation—ER stress"and"Pi qi deficiency—mitochondrial dysfunction",this article explores the assisting Pi transformation method for restoring the homeostasis of the body's energy metabolism to treat diabetes.This may be a new way to scientifically understand the Chinese medicine theory from the subcellular level,and provide a research direction for the molecular mechanism of the treatment of metabolic diseases by Chinese medicine compound of assisting Pi transformation.关键词
能量代谢/线粒体/内质网应激/糖尿病/助脾运化/中西医结合Key words
energy metabolism/mitochondria/endoplasmic reticulum stress/diabetes mellitus/assisting Pi transformation/integrative Chinese and Western medicine引用本文复制引用
温志歌,倪青..基于脾和内质网—线粒体相关性探析助脾运化法治疗糖尿病[J].中国中西医结合杂志,2024,44(5):608-615,8.基金项目
国家自然科学基金资助项目(No.82174354) （No.82174354）
中国中医科学院广安门医院临床医学研究中心建设专项经费项目(No.2022LYJSZX02) （No.2022LYJSZX02）
