中医药学报2024，Vol.52Issue(6)：111-115,5.DOI:10.19664/j.cnki.1002-2392.240127
中医药调控NLRP3炎症小体治疗支气管哮喘研究进展
Research Progress in the Treatment of Bronchial Asthma by Regulating NLRP3 Inflammasome with Traditional Chinese Medicine
摘要
Abstract
Bronchial asthma is a common chronic airway inflammatory disease in children and adults.Studies have found that the pathogenesis of asthma is closely related to the NLRP3 inflammasome.NLRP3 inflammasome can affect the occurrence and development of asthma by promoting airway inflammation,airway remodeling and mucus hypersecretion.Inhibiting the activation of NLRP3 inflammasome is a new direction of asthma treatment.Traditional Chinese medicine(TCM)is effective in treating asthma.A large number of studies have found that TCM can play a role in treating asthma by regulating the activation of inflammasome of NLRP3,and its regulation mechanism is closely related to signal pathways such as TLR4,AMPK,MAPK,NFKB,STAT3,and SIRT1,ATP/P2X7R axis and endoplasmic reticulum stress.This study reviewed the literature on the regulation of NLRP3 inflammasome by TCM in the treatment of asthma in recent years,aiming to provide reference for the clinical application of TCM in the treatment of asthma.关键词
中医药/NLRP3炎症小体/支气管哮喘Key words
Traditional Chinese medicine/NLRP3 inflammasome/Bronchial asthma分类
医药卫生引用本文复制引用
刘靖雷,王孟清,罗银河,姚冰,周智,马啸..中医药调控NLRP3炎症小体治疗支气管哮喘研究进展[J].中医药学报,2024,52(6):111-115,5.基金项目
国家自然科学基金项目(82174437) （82174437）
湖南中医药大学中医学国内一流建设学科(4901-020000200207) （4901-020000200207）
