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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

Chen Ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei Zhao Chang-Fa Fan

Zoological Research2024,Vol.45Issue(3):P.551-566,16.
Zoological Research2024,Vol.45Issue(3):P.551-566,16.DOI:10.24272/j.issn.2095-8137.2024.002

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

Chen Ling 1Su-Su Liu 2Yu-Ya Wang 2Gui-Tao Huo 3Yan-Wei Yang 3Nan Xu 4Hong Wang 5Yong Wu 2Yu-Fa Miao 3Rui Fu 5Yu-Wei Zhao 6Chang-Fa Fan2

作者信息

  • 1. College of Life Sciences,Northwest University,Provincial Key Laboratory of Biotechnology of Shaanxi Province,Xi’an,Shaanxi 710069,China Division of Animal Model Research,Institute for Laboratory Animal Resources,National Institutes for Food and Drug Control(NIFDC),Beijing 102629,China
  • 2. Division of Animal Model Research,Institute for Laboratory Animal Resources,National Institutes for Food and Drug Control(NIFDC),Beijing 102629,China
  • 3. National Center for Safety Evaluation of Drugs,National Institutes for Food and Drug Control(NIFDC),Beijing 100176,China
  • 4. Division of HIV/AIDS and Sexually Transmitted Virus Vaccines,Institute for Biological Products Control,National Institutes for Food and Drug Control(NIFDC),Beijing 102629,China
  • 5. Division of Laboratory Animal Monitoring,Institute for Laboratory Animal Resources,National Institutes for Food and Drug Control(NIFDC),Beijing 102629,China
  • 6. College of Life Sciences,Northwest University,Provincial Key Laboratory of Biotechnology of Shaanxi Province,Xi’an,Shaanxi 710069,China
  • 折叠

摘要

关键词

HRAS/THBS1/HCC driver factor/NASH/Fibrosis/Cirrhosis/HCC/Treatment evaluation

分类

医药卫生

引用本文复制引用

Chen Ling,Su-Su Liu,Yu-Ya Wang,Gui-Tao Huo,Yan-Wei Yang,Nan Xu,Hong Wang,Yong Wu,Yu-Fa Miao,Rui Fu,Yu-Wei Zhao,Chang-Fa Fan..Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice[J].Zoological Research,2024,45(3):P.551-566,16.

基金项目

supported by the National Institutes for Food and Drug Control,State Key Laboratory of Drug Regulatory Science。 ()

Zoological Research

OACSTPCD

2095-8137

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