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Liver as a new target organ in Alzheimer''''s disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng

Neural Regeneration Research2025，Vol.20Issue(3)：P.695-714,20.

Neural Regeneration Research2025，Vol.20Issue(3)：P.695-714,20.DOI:10.4103/1673-5374.391305

Liver as a new target organ in Alzheimer''''s disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

Beibei Wu ¹Yuqing Liu ¹Hongli Li ¹Lemei Zhu ²Lingfeng Zeng ²Zhen Zhang ³Weijun Peng⁴

作者信息

1. Department of Integrated Traditional Chinese&Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China
2. Academician Workstation,Changsha Medical University,Changsha,Hunan Province,China
3. Department of Integrated Traditional Chinese&Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China Yangsheng College of Traditional Chinese Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou Province,China Qinhuangdao Shanhaiguan Pharmaceutical Co.,Ltd,Qinhuangdao,Hebei Province,China
4. Department of Integrated Traditional Chinese&Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China National Clinical Research Center for Mental Disorder,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China
折叠

摘要

关键词

ABCA1/Alzheimer''s disease/amyloid-beta/apolipoprotein E/cholesterol metabolism/liver/liver X receptor/low-density lipoprotein receptor-related protein 1/peripheral clearance/tauroursodeoxycholic acid

分类

医药卫生

引用本文复制引用

Beibei Wu,Yuqing Liu,Hongli Li,Lemei Zhu,Lingfeng Zeng,Zhen Zhang,Weijun Peng..Liver as a new target organ in Alzheimer''''s disease:insight from cholesterol metabolism and its role in amyloid-beta clearance[J].Neural Regeneration Research,2025,20(3):P.695-714,20.

基金项目

financially supported by the Science and Technology Innovation Program of Hunan Province,No.2022RC1220(to WP) （to WP）

China Postdoctoral Science Foundation,No.2022M711733(to ZZ) （to ZZ）

the National Natural Science Foundation of China,No.82160920(to ZZ) （to ZZ）

Hebei Postdoctoral Scientific Research Project,No.B2022003040(to ZZ) （to ZZ）

Hunan Flagship Department of Integrated Traditional Chinese and Western Medicine(to WP)。（to WP）

Neural Regeneration Research

ISSN：1673-5374

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