首页|期刊导航|Neural Regeneration Research|Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You

Neural Regeneration Research2025，Vol.20Issue(3)：P.858-872,15.

Neural Regeneration Research2025，Vol.20Issue(3)：P.858-872,15.DOI:10.4103/NRR.NRR-D-23-01925

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

Xintian Ding ¹Chun Chen ²Heng Zhao ²Bin Dai ²Lei Ye ¹Tao Song ²Shuai Huang ²Jia Wang ²Tao You²

作者信息

1. Department of Orthopedics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui Province,China Department of Orthopedics,Provincial Hospital Affiliated to Anhui Medical University,Hefei,Anhui Province,China
2. Department of Orthopedics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui Province,China
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摘要

关键词

apoptosis/glycolysis/inflammatory response/microglia/neurons/polarization/spinal cord injury/Src homology 2-containing protein tyrosine phosphatase 2

分类

医药卫生

引用本文复制引用

Xintian Ding,Chun Chen,Heng Zhao,Bin Dai,Lei Ye,Tao Song,Shuai Huang,Jia Wang,Tao You..Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model[J].Neural Regeneration Research,2025,20(3):P.858-872,15.

基金项目

supported by the Natural Science Research Project of Anhui Province University, No.2023AH040394 (to TY) （to TY）

Hefei Comprehensive National Science Center Leading Medicine and Frontier Technology Research Institute Project, No.2023IHM01073 (to TY) （to TY）

the Natural Science Foundation of Anhui Province, Nos.2308085QH258 (to JW), 2008085MH246 (to TY)。（to JW）

Neural Regeneration Research

ISSN：1673-5374

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