首页|期刊导航|Journal of Biomedical Research|Upregulation of α-ENaC induces pancreatic β-cell dysfunction,ER stress,and SIRT2 degradation

Upregulation of α-ENaC induces pancreatic β-cell dysfunction,ER stress,and SIRT2 degradation

Xue Zhang Dan Zhang Lei Huo Xin Zhou Jia Zhang Min Li Dongming Su Peng Sun Fang Chen Xiubin Liang

Journal of Biomedical Research2024，Vol.38Issue(3)：P.241-255,15.

Journal of Biomedical Research2024，Vol.38Issue(3)：P.241-255,15.DOI:10.7555/JBR.37.20230128

Upregulation of α-ENaC induces pancreatic β-cell dysfunction,ER stress,and SIRT2 degradation

Xue Zhang ¹Dan Zhang ¹Lei Huo ²Xin Zhou ²Jia Zhang ³Min Li ⁴Dongming Su ⁴Peng Sun ³Fang Chen ³Xiubin Liang²

作者信息

1. Department of Pathophysiology,Nanjing Medical University,Nanjing,Jiangsu 211166,China Department of Pathology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210009,China
2. Department of Pathophysiology,Nanjing Medical University,Nanjing,Jiangsu 211166,China
3. Key Laboratory of Human Functional Genomics of Jiangsu Province,Department of Biochemistry and Molecular Biology,Nanjing Medical University,Nanjing,Jiangsu 211166,China
4. Department of Pathology,Nanjing Medical University,Nanjing,Jiangsu 211166,China
折叠

摘要

关键词

α-ENaC/pancreaticβ-cells/type 2 diabetes mellitus/endoplasmic reticulum stress/sirtuin 2

分类

医药卫生

引用本文复制引用

Xue Zhang,Dan Zhang,Lei Huo,Xin Zhou,Jia Zhang,Min Li,Dongming Su,Peng Sun,Fang Chen,Xiubin Liang..Upregulation of α-ENaC induces pancreatic β-cell dysfunction,ER stress,and SIRT2 degradation[J].Journal of Biomedical Research,2024,38(3):P.241-255,15.

基金项目

supported by the National Natural Science Foundation of China(Grant Nos.81870467 and 82270717 to XL,and 81970673 to FC) （Grant Nos.81870467 and 82270717 to XL,and 81970673 to FC）

China Postdoctoral Science Foundation(Grant No.2023M731630 to XZhang) （Grant No.2023M731630 to XZhang）

Postgraduate Research and Practice Innovation Program of Jiangsu Province(Grant No.KYCX21_1588 to XZhou). （Grant No.KYCX21_1588 to XZhou）

Journal of Biomedical Research

ISSN：1674-8301

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