北京大学学报（医学版）2024，Vol.56Issue(3)：375-383,9.DOI:10.19723/j.issn.1671-167X.2024.03.001
短期大气颗粒物暴露和MTNR1B基因多态性对甘油三酯-葡萄糖指数影响的家系研究
Associations of short-term ambient particulate matter exposure and MTNR1B gene with triglyceride-glucose index:A family-based study
摘要
Abstract
Objective:To explore the effects of short-term particulate matter(PM)exposure and the melatonin receptor 1B(MTNR1B)gene on triglyceride-glucose(TyG)index utilizing data from Fang-shan Family-based Ischemic Stroke Study in China(FISSIC).Methods:Probands and their relatives from 9 rural areas in Fangshan District,Beijing,were included in the study.PM data were obtained from fixed monitoring stations of the National Air Pollution Monitoring System.TyG index was calculated by fasting triglyceride and glucose concentrations.The associations of short-term PM exposure and rs10830963 polymorphism of the MTNR1B gene with the TyG index were assessed using mixed linear models,in which covariates such as age,sex,and lifestyles were adjusted for.Gene-environment inter-action analysis was furtherly performed using the maximum likelihood methods to explore the potential effect modifier role of rs10830963 polymorphism in the association of PM with TyG index.Results:A total of 4 395 participants from 2 084 families were included in the study,and the mean age of the study participants was(58.98±8.68)years,with 53.90％females.The results of association analyses showed that for every 10 μg/m3 increase in PM2.5 concentration,TyG index increased by 0.017(95％CI:0.007-0.027),while for per 10 μg/m3 increment in PM1o,TyG index increased by 0.010(95％CI:0.003-0.017).And the associations all had lagged effects.In addition,there was a positive association between the rs10830963 polymorphism and the TyG index.For per increase in risk allele G,TyG index was elevated by 0.040(95％CI:0.004-0.076).The TyG index was 0.079(95％CI:0.005-0.152)higher in carriers of the GG genotype compared with carriers of the CC genotype.The inter-action of rs10830963 polymorphism with PM exposure had not been found to be statistically significant in the present study.Conclusion:Short-term exposure to PM2.5 and PM10 were associated with higher TyG index.The G allele of rs10830963 polymorphism in the MTNR1B gene was associated with the elevated TyG index.关键词
颗粒物/吸入暴露/甘油三酯-葡萄糖指数/MTNR1B基因/家系研究Key words
Particulate matter/Inhalation exposure/Triglyceride-glucose index/MTNR1B gene/Family-based study分类
医药卫生引用本文复制引用
郭煌达,唐迅,李劲,陈大方,胡永华,吴涛,彭和香,王斯悦,侯天姣,李奕昕,章涵宇,王梦莹,武轶群,秦雪英..短期大气颗粒物暴露和MTNR1B基因多态性对甘油三酯-葡萄糖指数影响的家系研究[J].北京大学学报（医学版）,2024,56(3):375-383,9.基金项目
国家自然科学基金(82204135)、北京市自然科学基金(7232237)和中国博土后科学基金(BX2021021、2022M710249)Supported by the National Natural Science Foundation of China(82204135),Beijing Natural Science Foundation(7232237),and China Postdoctoral Science Foun-dation(BX2021021,2022M710249) （82204135）
