儿科药学杂志2024，Vol.30Issue(6)：29-33,5.DOI:10.13407/j.cnki.jpp.1672-108X.2024.06.008
脂联素、胰岛素水平与新生儿缺氧缺血性脑病神经发育结局的关系
Correlation between Adiponectin,Insulin Levels and Neurodevelopmental Outcomes of Neonates with Hypoxic-Ischemic Encephalopathy
摘要
Abstract
Objective:To explore the correlation between adiponectin(APN),insulin(INS)levels and neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy(NHIE).Methods:A total of 123 children with NHIE admitted into our hospital from Jun.2019 to May 2021 were extracted.According to the developmental quotient(DQ)of neurodevelopmental outcome,all children were divided into normal neurodevelopmental group(DQ＞75 points)and abnormal neurodevelopmental group(DQ≤75 points).During the same period,60 healthy neonates born in our hospital were enrolled in the control group.General data were collected,APN and INS levels were detected and compared between healthy children and children with NHIE,and NHIE children with different neurodevelopmental outcomes.Logistic regression was used to analyze the factors affecting the neurodevelopmental outcomes of NHIE,and Pearson correlation was used to analyze the correlation between APN and INS levels and DQ of children with NHIE.Predictive value of APN and INS levels to the neurodevelopmental outcomes of NHIE was analyzed according to receiver operating characteristic(ROC)curve.Results:APN levels in NHIE group were lower than those in control group,INS levels were higher than those in control group(P＜0.05).Among the 123 children with NHIE,101 cases had normal mental development and 22 cases had abnormal neurodevelopment.APN levels in abnormal neurodevelopmental group were lower than those in normal neurodevelopmental group,and INS levels were higher than those in normal neurodevelopmental group(P＜0.05).Logistic regression analysis showed that low levels of APN and INS were independent risk factors affecting the neurodevelopmental outcomes of NHIE(P＜0.05).According to Pearson correlation analysis,APN levels of children with NHIE were positively correlated with DQ score(r=0.561,P＜0.05),while INS levels were negatively correlated with DQ score(r=-0.464,P＜0.05).ROC analysis results showed that the area under the curve(AUC)of APN,INS and the combination of APN and INS in predicting the neurodevelopmental outcomes of NHIE were respectively 0.693,0.628 and 0.835,and the combined prediction efficiency of APN and INS was higher than that of single detection(P＜0.05).Conclusion:APN and INS levels are significantly lower in children with NHIE,APN levels are positively correlated with DQ score,INS levels are negatively correlated with DQ score,and APN combined with INS examination is of high value in predicting neurodevelopmental outcomes in NHIE.关键词
新生儿缺氧缺血性脑病/脂联素/胰岛素/神经发育结局Key words
neonatal hypoxic-ischemic encephalopathy/adiponectin/insulin/meurodevelopmental outcomes分类
医药卫生引用本文复制引用
杨斌,赵妤卓,王雅清..脂联素、胰岛素水平与新生儿缺氧缺血性脑病神经发育结局的关系[J].儿科药学杂志,2024,30(6):29-33,5.基金项目
衡水市科技计划项目,编号2020014035Z. （）
