低分子肝素辅助治疗D-二聚体升高的新生儿继发性肺动脉高压的疗效OACSTPCD

Objective:To probe into the efficacy of low molecular weight heparin(LMWP)in the adjuvant treatment of secondary pulmonary hypertension(PH)in neonates with elevated D-dimer.Methods:From Jun.2020 to May 2023,a total of 100 neonates with secondary PH and plasma D-dimer＞1,000 ng/mL hospitalized in neonatal intensive care unit of Huadu Hospital Affiliated to Southern Medical University were extracted to be divided into nasal continuous airway positive pressure(NCPAP)group and invasive mechanical ventilation(IMV)group based on different oxygen therapy methods,with 50 cases in each group.Both groups were divided into the observation group A and B,and control group A and B subgroups according to whether or not receiving LMWP therapy,with 25 cases in each group.Pulmonary artery systolic blood pressure(PASP),D-dimer level and occurrence of adverse drug reactions in each group were compared and analyzed within 72 h.Results:There were no significant differences in gestational age,age,and underlying diseases among all groups(P＞0.05).The median level of D-dimer in observation group A and B after treatment were significantly lower than those in corresponding control group A and B and before treatment(P＜0.05).The median level of D-dimer in control group A and B were lower than those before treatment,yet there was no statistically significant difference(P＞0.05).The total effective rate of observation group A and B was respectively 88％and 84％,higher than that of corresponding control group A and B(P＜0.05).Conclusion:Intravascular obstruction induced by hypercoagulability or thrombosis may be an important cause of neonatal secondary PH,and the adjuvant treatment with LMWP can improve the curative effect.