儿科药学杂志2024，Vol.30Issue(6)：33-37,5.DOI:10.13407/j.cnki.jpp.1672-108X.2024.06.009
低分子肝素辅助治疗D-二聚体升高的新生儿继发性肺动脉高压的疗效
Efficacy of Low Molecular Weight Heparin in the Adjuvant Treatment of Secondary Pulmonary Hypertension in Neonates with Elevated D-Dimer
摘要
Abstract
Objective:To probe into the efficacy of low molecular weight heparin(LMWP)in the adjuvant treatment of secondary pulmonary hypertension(PH)in neonates with elevated D-dimer.Methods:From Jun.2020 to May 2023,a total of 100 neonates with secondary PH and plasma D-dimer＞1,000 ng/mL hospitalized in neonatal intensive care unit of Huadu Hospital Affiliated to Southern Medical University were extracted to be divided into nasal continuous airway positive pressure(NCPAP)group and invasive mechanical ventilation(IMV)group based on different oxygen therapy methods,with 50 cases in each group.Both groups were divided into the observation group A and B,and control group A and B subgroups according to whether or not receiving LMWP therapy,with 25 cases in each group.Pulmonary artery systolic blood pressure(PASP),D-dimer level and occurrence of adverse drug reactions in each group were compared and analyzed within 72 h.Results:There were no significant differences in gestational age,age,and underlying diseases among all groups(P＞0.05).The median level of D-dimer in observation group A and B after treatment were significantly lower than those in corresponding control group A and B and before treatment(P＜0.05).The median level of D-dimer in control group A and B were lower than those before treatment,yet there was no statistically significant difference(P＞0.05).The total effective rate of observation group A and B was respectively 88％and 84％,higher than that of corresponding control group A and B(P＜0.05).Conclusion:Intravascular obstruction induced by hypercoagulability or thrombosis may be an important cause of neonatal secondary PH,and the adjuvant treatment with LMWP can improve the curative effect.关键词
低分子肝素/肺动脉高压/D-二聚体/新生儿/安全性Key words
low molecular weight heparin/pulmonary hypertension/D-dimer/neonate/safety分类
医药卫生引用本文复制引用
陈波,李广洪,白波,罗惠玲,黄学良,张燕钦,黄惠仪,李菲..低分子肝素辅助治疗D-二聚体升高的新生儿继发性肺动脉高压的疗效[J].儿科药学杂志,2024,30(6):33-37,5.基金项目
广州市科技计划项目,编号202102080666. （）
