广东医学2024，Vol.45Issue(5)：596-602,7.DOI:10.13820/j.cnki.gdyx.20240848
血淋巴细胞亚群对食管癌患者PD-1治疗效果的预测价值
The predictive value of peripheral blood lymphocyte subsets for PD-1 therapy in esophageal cancer patients
摘要
Abstract
Objective To explore the relationship between peripheral blood lymphocyte subsets and the prognosis of PD-1 therapy in esophageal cancer patients.Methods A total of 127 advanced esophageal cancer patients treated with immunotherapy at Guangdong Provincial People's Hospital were selected.Peripheral blood lymphocyte subsets were measured before and after treatment,and clinical data of the patients were collected.The relationship between lymphocyte subsets and the efficacy of PD-1 therapy was retrospectively analyzed.Results Before treatment,the proportion of CD3+cells(P＜0.05)and CD8+cells(P＜0.001)in the remission group(PR)was significantly lower than that in the non-remission group(PD+SD),while the CD4+/CD8+ratio(P＜0.01)and NK cell proportion(P＜0.05)were signifi-cantly higher than those in the non-remission group.After treatment,the proportion of peripheral blood CD8+cells in the remission group was significantly lower than that in the non-remission group(P＜0.05),while the proportion of CD19+cells was higher than that in the non-remission group(P＜0.05).The △CD19+(P＜0.05,the difference value of CD19+before and after treatment,the same below)and △CD19+CD5+(P＜0.05)in the remission group were signifi-cantly higher than those in the non-remission group.The combination of NK before treatment,CD8+before and after treatment,and three factors predicted the prognosis of esophageal cancer immunotherapy with the highest diagnostic effica-cy(AUC=0.840),the highest Youden index(0.625),and higher positive predictive value(0.812)and negative pre-dictive value(0.813).Conclusion A high CD4+/CD8+ratio,high proportion of NK cells,and low proportion of CD8+cells in the remission group indicate a good prognosis for immunotherapy.The combination of CD8+before and after treatment and NK before treatment has good diagnostic value for the efficacy of immunotherapy.关键词
食管癌/免疫治疗/PD-1治疗/淋巴细胞亚群/免疫治疗预后/免疫治疗预后评估Key words
esophageal cancer/immunotherapy/PD-1 treatment/lymphocyte subpopulations/immunotherapy prognosis/prognostic evaluation of immunotherapy引用本文复制引用
陈翼翔,陈梦圆,张华斌,林夏怡,乔贵宾,赖晓嵘,李子俊..血淋巴细胞亚群对食管癌患者PD-1治疗效果的预测价值[J].广东医学,2024,45(5):596-602,7.基金项目
广州市科技计划项目(201804010458) （201804010458）
