广东医学2024，Vol.45Issue(5)：603-609,7.DOI:10.13820/j.cnki.gdyx.20233566
利用DXA评估系统性红斑狼疮患者中肌少症的现患率
Assessment of sarcopenia prevalence in patients with systemic lupus erythematosus using DXA
摘要
Abstract
Objective To evaluate the prevalence of sarcopenia in patients with systemic lupus erythematosus(SLE),analyze changes in body composition in patients with SLE comorbid with sarcopenia,and explore the risk factors for sarcopenia in SLE patients.Methods A total of 114 patients with SLE and 114 healthy volunteers were included.Dual-energy X-ray absorptiometry(DXA)was used to measure muscle mass in both groups.Grip strength and gait speed were assessed to evaluate muscle strength and physical performance in patients.Sarcopenia diagnosis and staging were performed according to the criteria of the European Working Group on Sarcopenia in Older People and the Asian Working Group for Sarcopenia.Patients with SLE were divided into sarcopenia and non-sarcopenia groups,and differ-ences in body composition and bone density between the groups were compared.Factors influencing sarcopenia comorbidity in SLE patients were analyzed.Results The mean duration of SLE was(79.6±72.8)months.45.6％(n=52)of SLE patients had comorbid sarcopenia,among which 22.8％(n=26)were in the pre-sarcopenia stage,16.7％(n=19)were in the sarcopenia stage,and 6.1％(n=7)were in the severe sarcopenia stage.Patients with sarcopenia comorbidity in the SLE group had lower body weight,body mass index,fat mass index,whole-body lean tissue content,lean mass index,whole-body lean mass,and lean mass index compared to non-sarcopenia SLE patients and healthy controls.Bone mineral content,lumbar spine,and femoral bone density in sarcopenia subgroups were significantly lower than those in healthy controls.Multivariate regression analysis showed that body mass index(OR=0.61,P＜0.001,95％CI:0.49-0.75)and occupational labor intensity(OR=2.0,P=0.009,95％CI:1.19-3.34)were factors influencing sarcope-nia comorbidity in SLE patients.Conclusion Approximately half of SLE patients have comorbid sarcopenia,with de-creased fat,muscle content,and bone density at important sites in sarcopenia comorbid SLE patients.Body mass index and occupational labor intensity are factors influencing the occurrence of sarcopenia in SLE patients.关键词
系统性红斑狼疮/体成分/双能X线吸收法/肌少症/骨密度Key words
systemic lupus erythematosus/body composition/dual-energy X-ray absorptiometry/sarcopenia/bone mineral density分类
医药卫生引用本文复制引用
李朝霞,欧阳辉,黎晓萱,徐浩,周毅..利用DXA评估系统性红斑狼疮患者中肌少症的现患率[J].广东医学,2024,45(5):603-609,7.基金项目
广州市基础研究计划基础与应用基础研究项目(2023A04J1916) （2023A04J1916）
暨南大学中央高校基本科研业务费项目(自然科学类)(21622311) （自然科学类）
