广东医学2024，Vol.45Issue(5)：620-625,6.DOI:10.13820/j.cnki.gdyx.20233485
血清sPD-L2与MUC5AC在肺炎支原体肺炎合并气道黏液栓患儿中的表达及临床意义
Expression and clinical significance of serum sPD-L2 and MUC5AC in children with mycoplasma pneumonia complicated by airway mucus plug
摘要
Abstract
Objective To investigate the expression and clinical significance of serum soluble programmed cell death ligand-2(sPD-L2)and hyaluronic acid receptor Layilin(LAYN)in children with Mycoplasma pneumoniae pneumonia(MPP)complicated by airway mucus plug.Methods A total of 184 children with MPP from January 2018 to January 2022 were selected as the MPP group,and 60 children undergoing elective inguinal hernia repair in the same peri-od were selected as the control group.According to whether airway mucus plug was combined under bronchoscopy,the MPP group was divided into the simple MPP group(130 cases)and the MPP combined with mucus plug group(54 ca-ses).Enzyme-linked immunosorbent assay was used to detect serum sPD-L2 and LAYN levels.Multivariate logistic re-gression analysis was used to analyze the risk factors affecting the formation of airway mucus plug in children with MPP.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum sPD-L2 and LAYN for MPP combined with airway mucus plug.Results The serum levels of sPD-L2 and LAYN in the MPP group were sig-nificantly higher than those in the control group,and the differences were statistically significant(all P＜0.05).In the MPP group with airway mucus plug,the fever duration,serum C-reactive protein,pleural effusion,lung collapse,in-volvement of ≥2 lung lobes,sPD-L2,and LAYN levels were higher than those in the simple MPP group,and the differ-ences were statistically significant(all P＜0.05).The serum levels of sPD-L2 and LAYN in children with MPP com-bined with airway mucus plug were significantly positively correlated with white blood cell count,C-reactive protein,and percentage of neutrophils(all P＜0.05).Fever duration,elevated serum sPD-L2,and LAYN were independent risk factors for the formation of airway mucus plug in MPP.The combined ROC curve for fever duration,sPD-L2,and LAYN predicting MPP combined with airway mucus plug had an area under the curve of 0.893,higher than the single indicator detection of 0.820,0.721,and 0.789,with statistically significant differences(Z=4.302,5.618,4.518,all P＜0.001).Conclusion The elevated serum levels of sPD-L2 and LAYN in children with MPP combined with airway mu-cus plug,along with prolonged fever duration,indicate independent risk factors for the formation of airway mucus plug.The combination of these three factors helps assess the presence of MPP combined with airway mucus plug.关键词
支原体肺炎/气道黏液栓/可溶性程序性死亡因子配体-2/Layilin/预测价值Key words
Mycoplasma pneumonia/airway mucus plug/sPD-L2/Layilin/predictive value分类
医药卫生引用本文复制引用
王可,于京虎,裴艳莹..血清sPD-L2与MUC5AC在肺炎支原体肺炎合并气道黏液栓患儿中的表达及临床意义[J].广东医学,2024,45(5):620-625,6.基金项目
黑龙江省医药卫生科研课题(2019352) （2019352）
