广东医学2024，Vol.45Issue(5)：656-660,5.DOI:10.13820/j.cnki.gdyx.20233125
亚低温通过影响ACSL4调节铁死亡改善脑缺血再灌注损伤的研究进展
Progress in the study of mild hypothermia improving brain ischemia-reperfusion injury by regulating iron death via ACSL4
摘要
Abstract
Brain ischemia-reperfusion injury represents a more severe phase occurring after cerebral ischemia.Currently,clinical treatments mainly focus on pharmacotherapy and surgical thrombolysis.Iron death,as a unique form of cell death,has been demonstrated to play a distinct role in cerebral ischemia and reperfusion injury,which is related to the accumulation of lipid peroxides mediated by acyl-CoA synthetase long-chain family member 4(ACSL4).Recent studies have found that mild hypothermia,as a clinically accepted physical therapy,may exert therapeutic effects on brain ischemia-reperfusion injury by preventing lipid oxidation,improving cerebral ischemia hypoxia,regulating coagulation enzyme function and iron metabolism,inhibiting excitotoxicity,reducing inflammation and edema,and decreasing blood-brain barrier permeability,ultimately silencing iron death.This review aims to analyze how mild hypothermia regulates iron death by affecting ACSL4,thereby providing new pathways and methods for mechanistic research and clinical treat-ment of brain ischemia-reperfusion injury.关键词
亚低温/ACSL4/脑缺血再灌注损伤/铁死亡Key words
mild low temperature/ACSL4/cerebral ischemia-reperfusion injury/ferroptosis分类
医药卫生引用本文复制引用
谭璐璐,方鑫富,陈兴华..亚低温通过影响ACSL4调节铁死亡改善脑缺血再灌注损伤的研究进展[J].广东医学,2024,45(5):656-660,5.基金项目
广西中医脑病临床研究中心项目(桂科AD20238028) （桂科AD20238028）
广西高等学校高水平创新团队及卓越学者计划(桂教人才[2020]6号) （桂教人才[2020]6号）
广西中医药大学第一附属医院学术团队建设项目(院字[2018]146号) （院字[2018]146号）
广西中医药重点学科建设项目(GZXK-Z-20-13) （GZXK-Z-20-13）
