摘要
Abstract
Objective To investigate the influence of cerebral small vessel disease(CSVD)on cognitive and emotional impairment in patients with Parkinson's disease(PD).Methods A total of 131 patients with PD were hospitalized or attended the outpatient service of Department of Neurology,Hulunbuir People's Hospital,from September 2021 to October 2022 were enrolled,among whom there were 56 patients with primary PD(PD group)and 75 patients with primary PD combined with CSVD(PD+CSVD group).The patients were analyzed in terms of general information,scores of related scales,and imaging data,and the two groups were compared in terms of the scores of cognitive and affective scales and the correlation of the imaging load scores and types of CSVD with the scores of cognitive and affective scales.Results There were significant differences between the two groups in history of hypertension,history of diabetes,triglyceride(TG),high-density lipoprotein cholesterol,homocysteine,supine/orthostatic hypotension,Mini-Mental State Examination(MMSE)score,Montreal Cognitive Assessment(MoCA)score,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score,and CSVD load score(P<0.05).For the patients in the PD+CSVD group,CSVD load score was significantly positively correlated with TG(P=0.044)and was significantly negatively correlated with MMSE and MOCA cognitive scores(P<0.01).White matter hypertensity(WMH),cerebral microbleeds(CMB),and lacunar space(LA)were significantly negatively correlated with MMSE cognitive scores(P<0.05),and WMH and LA were significantly negatively correlated with MOCA cognitive scores(P<0.05).For the patients in the PD+CSVD group,CSVD load score was significantly positively correlated with HAMA and HAMD emotional scores(P<0.001).WMH,peripheral vascular space,and CMB were significantly positively correlated with HAMA emotional scores(P<0.05),and LA and CMB were significantly positively correlated with HAMD emotional scores(P=0.005).Conclusions Total CSVD load score can objectively evaluate the influence of CSVD severity on the non-motor symptoms of PD patients,which provides a new direction for monitoring the condition of PD patients and performing subsequent management among clinicians.关键词
帕金森病/脑小血管病/认知障碍/情感障碍Key words
Parkinson's disease/cerebral small vessel disease/cognitive impairment/affective disorders分类
医药卫生
