江西科学2024，Vol.42Issue(3)：482-489,8.DOI:10.13990/j.issn1001-3679.2024.03.005
靶向PD-1/PD-L1蛋白-蛋白相互作用小分子抑制剂研究进展
Research Progress of Small Molecule Inhibitors Targeting PD-1/PD-L1 Protein-protein Interaction
摘要
Abstract
Objective:To elucidate the interaction mechanism of PD-1/PD-L1 and its role in im-mune escape of cancer cells,and to introduce novel small molecule inhibitors targeting PD-1/PD-L1 developed in recent years.Methods:Literature on PD-1/PD-L1 inhibitors from domestic and foreign sources was searched,and the small molecule inhibitors targeting PD-1/PD-L1 developed in recent years were collated and compared.Results:PD-1/PD-L1 inhibitors mainly include mon-oclonal antibodies,peptidomimetic inhibitors,and small molecule inhibitors,which mainly exert their effects by blocking the interaction between PD-1 and PD-L1,forming PD-L1 dimers.Signifi-cance:The development of small molecule drugs targeting PD-1/PD-L1 is a challenging process.Small molecule inhibitors have better abilities to inhibit tumor growth and migration compared to an-tibodies.The design strategies of small molecule inhibitors in recent years have provided new in-sights for the development of small molecule inhibitors.关键词
免疫逃逸/PD-1/PD-L1/单克隆抗体/小分子抑制剂Key words
immune escape/PD-1/PD-L1/monoclonal antibody/small molecule inhibitors分类
医药卫生引用本文复制引用
宋伟,段学民,程建昕..靶向PD-1/PD-L1蛋白-蛋白相互作用小分子抑制剂研究进展[J].江西科学,2024,42(3):482-489,8.基金项目
国家自然科学基金项目(22063004). （22063004）
