解放军医学院学报2024，Vol.45Issue(2)：112-117,6.DOI:10.12435/j.issn.2095-5227.2023.159
常规超声联合超声造影在不同大小乳腺结节诊断中的应用价值
Value of conventional ultrasound combined with contrast-enhanced ultrasound in diagnosis of breast lesions of different sizes
摘要
Abstract
Background Ultrasound(US)and contrast-enhanced ultrasound(CEUS)are commonly used for diagnosis of breast nodules.The diagnostic efficacy of ultrasound combined with ultrasonography varies with different sizes of breast nodules,but the diagnostic efficacy of ultrasonography for breast lesions<1.0 cm is unknown.Objective To analyze the diagnostic efficiency of conventional ultrasound combined with contrast-enhanced ultrasound in breast nodules of different sizes.Methods Clinical data and ultrasound images of 847 patients who underwent routine ultrasound and CEUS with definite pathological findings in the Ultrasonography Department of the First Medical Center of Chinese PLA General Hospital from January 2021 to December 2022 were analyzed retrospectively.The nodules were divided into three groups according to their sizes:group 1 with size≤1.0 cm,group 2 with size 1.0-2.0 cm,and group 3 with size>2.0 cm.The CEUS characteristics of breast nodules in the three groups and the diagnostic efficacy of US combined with CEUS for breast nodules were compared.Results All patients were female and their age ranged from 18 to 75 years with an average age of 45 years.The mean size of all lesions was 1.9 cm and ranged from 0.3 to 13.9 cm.There were 194 cases in the group 1(148 benign and 46 malignant),358 cases in the group 2(220 benign and 138 malignant),and 295 cases in the group 3(135 benign and 160 malignant).The characteristics of CEUS in malignant lesions were centripetal enhancement,hyperenhancement,heterogeneous enhancement,ill-defined margin,irregular shape,enlarged enhancement scope and radial enhancement.The CEUS characteristics(enhancement uniformity,presence of filling defects and time to regression)of breast malignant lesions of different sizes differed,and the areas under the curve of the working characteristics of US combined CEUS for subjects with breast nodules in the three groups were 0.844,0.932 and 0.928,respectively,with the area under the curve of the group of≤1 cm being significantly lower than that of the other two groups(P<0.005).Conclusion CEUS features of breast lesions of different sizes are different.The diagnostic efficacy of conventional US combined with CEUS for breast nodules of different sizes varies,and the diagnostic efficacy is higher for lesions>1.0 cm.关键词
乳腺结节/超声/超声造影/结节大小/良恶性结节Key words
breast nodule/ultrasound/contrast-enhanced ultrasound/nodule size/benign and malignant nodules分类
医药卫生引用本文复制引用
付乃芹,李俊康,姜莹,李诗雨,牛瑞兰,金志瑛,王知力..常规超声联合超声造影在不同大小乳腺结节诊断中的应用价值[J].解放军医学院学报,2024,45(2):112-117,6.基金项目
国家自然科学基金项目(82071925) （82071925）
军队课题(22BJZ23) （22BJZ23）
军队课题(LB20211A010011) （LB20211A010011）
