临床小儿外科杂志2024，Vol.23Issue(5)：452-457,6.DOI:10.3760/cma.j.cn101785-202206023-010
耐甲氧西林和甲氧西林敏感性金黄色葡萄球菌致儿童急性骨髓炎的临床特征比较
Clinical features of acute osteomyelitis due to methicillin-resistant Staphylococcus aureus in children
摘要
Abstract
Objective To explore the clinical characteristics of acute osteomyelitis(AO)due to methi-cillin-resistant Staphylococcus aureus(MRSA)versus AO due to methicillin-susceptible Staphylococcus aureus(MSSA)in children.Methods From November 2017 to March 2022,68 AO children cultured positively Staphylococcus aureus in pus were recruited from Children's Hospital Affiliated to Shandong University.They were assigned into two groups of MRSA(n=24)and MSSA(n=44).Two groups were compared with regards to peak onset temperature,inflammatory parameters,age,gender,time of onset,location of onset,arthritis,hospi-talization stay,number of operations and complications.Results No statistically significant inter-group differ-ences existed in gender,site of onset,complications,age,duration of symptoms pre-admission,peak onset tem-perature,degree of leukocyte elevation,degree of neutrophil elevation and degree of erythrocyte sedimentation rate(ESR).Statistically significant inter-group differences existed in concurrent arthritis,hospitalization stay[(39.75±15.16)vs.(29.52±8.45)day],operative duration[(3.58±1.61)vs.(2.68±0.77)],C-reac-tive protein elevation(CRP)[(93.99±61.38)vs.(65.90±49.14)mg/L].Among children with CRP/ESR elevation(18 cases in MRSA group and 40 cases in MSSA group),ratio of CRP to ESR in MRSA group was statistically significant compared with that in MSSA group[(2.17±0.98)vs.(1.46±1.07)].Conclusions As compared with MSSA-induced AO in children,AO due to MRSA is more likely to be accompanied with arthri-tis,requiring more surgical procedures and a longer hospital stay.Degree of CRP elevation and ratio of CRP to ESR are higher in children with OA due to MRSA.关键词
骨髓炎/耐甲氧西林金黄色葡萄球菌/外科手术/儿童Key words
Osteomyelitis/Methicillin-Resistant Staphylococcus Aureus/Surgical Procedures,Opera-tive/Child引用本文复制引用
贾海亭,王玉亭,孙琳,刘涛,于嘉智,王春华..耐甲氧西林和甲氧西林敏感性金黄色葡萄球菌致儿童急性骨髓炎的临床特征比较[J].临床小儿外科杂志,2024,23(5):452-457,6.基金项目
山东省儿童健康与疾病临床医学研究中心立项项目(RC006) Shandong Provincial Clinical Research Center for Children's Health and Disease(RC006) （RC006）
