临床小儿外科杂志2024，Vol.23Issue(5)：464-468,5.DOI:10.3760/cma.j.cn101785-202203047-012
细胞减灭术联合腹腔热灌注化疗在局部反复复发肾母细胞瘤治疗中的应用
Application of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for locally recur-rent Wilms tumor
常晓峰 1王焕民 1王佳荣 2孟德光 2秦红 1杨维 1成海燕 1朱志云1
作者信息
- 1. 国家儿童医学中心首都医科大学附属北京儿童医院肿瘤外科,北京 100045
- 2. 北京儿童医院保定医院肿瘤外科,保定 071000
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of cytoreductive surgery(CRS)plus hyperthermic intra-peritoneal chemotherapy(HIPEC)for locally recurrent nephroblastoma.Methods For this retrospective stud-y,six children with locally recurrent nephroblastoma were recruited from January 2019 to January 2022.Personal demographics(gender,age & disease site),previous protocols,treatment plans,surgical procedures,HIPEC,postoperative management and follow-ups were collected.Results All of them had unilateral lesions.Radical nephrectomy(n=5)and nephron sparing surgery(NSS,n=1)were performed.Two cases of Children's On-cology Group(COG)stage Ⅲ received chemoradiotherapy while another two of stage Ⅱ had chemotherapy a-lone.The remainders received preoperative chemotherapy and postoperative International Society of Pediatric Oncology(SIOP)stage was both stage Ⅱ.The shortest time to recurrence was 1.5 months while the longest one 10 months.All abdominopelvic lesions were removed without distant metastases.Five cases received local radiotherapy and intensive postoperative chemotherapy.CRS plus HIPEC were offered without any perioperative life-threatening complication.The median follow-up period was 14(2-32)months).The outcomes were long-term survival(n=4)and tumor progression(n=2).Conclusions The prognosis for locally recurrent nephroblastoma remains unsatifactory.However,with an aid of adjunctive chemotherapy,CRS plus HIPEC are capable of maximizing the eradication of residual tumor cells and thus facilitating local tumor control.关键词
细胞减灭术/腹腔热灌注化疗/肾母细胞瘤/外科手术/儿童Key words
Cytoreductive Surgery/Hyperthermic Intraperitoneal Chemotherapy/Wilms Tumor/Surgi-cal Procedures,Operative/Child引用本文复制引用
常晓峰,王焕民,王佳荣,孟德光,秦红,杨维,成海燕,朱志云..细胞减灭术联合腹腔热灌注化疗在局部反复复发肾母细胞瘤治疗中的应用[J].临床小儿外科杂志,2024,23(5):464-468,5.
