生物加工过程2024，Vol.22Issue(3)：237-250,14.DOI:10.3969/j.issn.1672-3678.2024.03.001
转录因子在微生物细胞工厂构建中的应用
Application of transcription factors in the construction of microbial cell factories
摘要
Abstract
The employment of microbial cell factories has become a feasible approach for the green and sustainable production,which is environmentally friendly and attracts much attention.With the development of synthetic biology,the efficient and intelligent production of microbial cell factories has become a topic of tremendous research hot spot.The efficient synthesis of target products in microorganisms relies on the regulation and optimization of metabolic pathways.Meanwhile,transcription factors are common regulatory elements that play an important role in the construction of microbial cell factories.Transcription factors has been widely applied in the construction of biosensors,high-throughput screening,and the engineering of chassis cells.Starting from the regulatory mechanism of transcription factors,we review the mining,prediction and identification methods of transcription factors,and comprehensively summarize and discusse the application of transcription factors in the construction of microbial cell factories to provide reference for related research.关键词
转录因子/调控元件/转录调控/微生物细胞工厂/生物制造Key words
transcription factor/regulatory element/transcriptional regulation/microbial cell factory/biomanufacture分类
生物科学引用本文复制引用
史彩芳,李敬知,孟栋,李春,王颖..转录因子在微生物细胞工厂构建中的应用[J].生物加工过程,2024,22(3):237-250,14.基金项目
国家重点研发计划(2019YFA0905700) （2019YFA0905700）
国家自然科学基金(22078020) （22078020）
