摘要
Abstract
Objective To observe the effects of Shenfu Injection on hemodynamics and clinical efficacy in patients with chronic heart failure,acute decompensation,and cardiogenic shock.Methods Sixty patients with chronic heart failure,acute decompensation,and cardiogenic shock admitted to the hospital from January 2021 to July 2023 were selected.They were randomly divided into a control group(norepinephrine)and an observation group(norepinephrine+Shenfu injection)using a random number table method,with 30 patients in each group,Observe the hemodynamic parameters(SVV,CI,SVRI),sequential organ failure assessment score(SOFA),norepinephrine dosage,N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)levels before and after treatment in two groups of continuous cardiac output monitoring(PiCCO)with pulse indication before and after treatment Echocardiographic indicators[left ventricular short axis shortening rate(LVFS),left ventricular ejec-tion fraction(LVEF),left ventricular end diastolic diameter(LVEDD)],and the incidence of cardi-ovascular composite endpoint events.Results After treatment,the SVV of the observation group was lower than that of the control group,while the CI and SVRI were higher than those of the control group(P＜0.05);After treatment,the SOFA score and norepinephrine dosage in the observation group were lower than those in the control group(P＜0.05);After treatment,LVFS and LVEF in the observation group were higher than those in the control group,while LVEDD and NT-proBNP were lower than those in the control group(P＜0.05);After treatment,LVFS and LVEF in the ob-servation group were higher than those in the control group,while LVEDD was lower than that in the control group(P＜0.05);The incidence of cardiac death was 26.67％in the observation group and 40.00％in the control group,with no statistically significant difference(P＞0.05).Conclusions Shenfu Injection can reduce the use of norepinephrine in the treatment of acute decompensation com-bined with cardiogenic shock in chronic heart failure,and has good clinical efficacy.关键词
慢性心力衰竭/失代偿期/心源性休克/参附注射液/血流动力学Key words
Chronic heart failure/Period of loss of compensation/Cardiogenic shock/Shen-fu Injection/Hemodynamics
