生殖医学杂志2024，Vol.33Issue(6)：817-823,7.DOI:10.3969/j.issn.1004-3845.2024.06.020
反复妊娠丢失中同种免疫功能异常机制的研究进展
Progress in mechanism research of alloimmune dysfunction in recurrent pregnancy loss
摘要
Abstract
Recurrent pregnancy loss(RPL),which has an incidence of 2％～5％women of childbearing age,is a reproductive disease caused by multiple etiologies and seriously,endangers the physical and mental health of patients.A growing number of studies have shown that alloimmune dysfunctions are involved in the development of RPL by affecting immune homeostasis at the maternal-fetal interface,endometrial decidualization,trophoblast apoptosis and placental angiogenesis.Innate immune abnormalities including abnormal numbers and activities of natural killer cells,macrophages and dendritic cells and adaptive immune abnormalities including abnormal numbers and activities of CD4+helper T cells(Th1,Th2 and Th17),CD4+CD25+Foxp3+regulatory T cells,CD8+T cells,γδ-T cells,CD19+regulatory B cells and cytokines together constitute the immune disorder model of alloimmune RPL,but the specific mechanism needs to further investigate.This article reviews the current alloimmunization etiological mechanism researches and progress of RPL.关键词
反复妊娠丢失/流产/同种免疫/固有免疫/适应性免疫Key words
Recurrent pregnancy loss/Miscarriage/Alloimmune/Innate immune/Adaptive immune分类
医药卫生引用本文复制引用
付琬婷,胡琳莉..反复妊娠丢失中同种免疫功能异常机制的研究进展[J].生殖医学杂志,2024,33(6):817-823,7.基金项目
国家自然科学基金(82171658) （82171658）
