生殖医学杂志2024，Vol.33Issue(6)：831-836,6.DOI:10.3969/j.issn.1004-3845.2024.06.022
早发性卵巢功能不全遗传因素中相关基因改变的研究进展
Advances in research on genetic changes related to premature ovarian insufficiency
摘要
Abstract
Premature ovarian insufficiency(POI)refers to the occurrence of menstrual and hormonal abnormalities in women before the age of 40.In recent years,the incidence rate of POI has increased year by year,attracting strong attention from scholars at home and abroad.With the development of technologies such as whole exome sequencing and whole genome sequencing,different POI candidate genes and pathogenic genes have been discovered.More and more studies have confirmed that gene mutations are involved in the pathological and physiological processes of POI,which has greatly increased people's understanding of its genetic etiology.In this paper,we review the latest progress in POI related gene changes and their molecular mechanisms from three aspects:DNA damage repair and homologous recombination related genes,transcription factor related genes,and ovarian function related genes,in order to clarify the diversity of its pathogenesis and provide new ideas for genetic screening and the treatment of POI.关键词
早发性卵巢功能不全/基因突变/病因Key words
Premature ovarian insufficiency/Genes mutation/Etiology分类
医药卫生引用本文复制引用
王云迪,吉日嘎拉赛罕 巴达日其,王煜..早发性卵巢功能不全遗传因素中相关基因改变的研究进展[J].生殖医学杂志,2024,33(6):831-836,6.基金项目
内蒙古自治区草原英才创新人才项目(2022TD014) （2022TD014）
内蒙古医科大学科技成果转化项目(YKD2020CGZH007) （YKD2020CGZH007）
国家自然科学基金后续项目(RZ2000002917) （RZ2000002917）
内蒙古医科大学致远人才计划(DC2100002816) （DC2100002816）
内蒙古科技计划项目(2023KJHZ0038) （2023KJHZ0038）
内蒙古医科大学博士点建议单位资金匹配项目(RC2300002962) （RC2300002962）
