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Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

Mariola Olkowicz Khaled Ramadan Hernando Rosales-Solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn

药物分析学报（英文）2024，Vol.14Issue(2)：196-210,15.

药物分析学报（英文）2024，Vol.14Issue(2)：196-210,15.DOI:10.1016/j.jpha.2023.08.001

Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

Mariola Olkowicz ¹Khaled Ramadan ²Hernando Rosales-Solano ³Miao Yu ⁴Aizhou Wang ²Marcelo Cypel ⁵Janusz Pawliszyn³

作者信息

1. Department of Chemistry,University of Waterloo,Waterloo,ON,Canada||Jagiellonian Centre for Experimental Therapeutics(JCET),Jagiellonian University,Krakow,Poland
2. Lamer Thoracic Surgery Research Laboratories,Toronto General Hospital Research Institute,University Health Network,Toronto,ON,Canada
3. Department of Chemistry,University of Waterloo,Waterloo,ON,Canada
4. The Jackson Laboratory,JAX Genomic Medicine,Farmington,CT,USA
5. Lamer Thoracic Surgery Research Laboratories,Toronto General Hospital Research Institute,University Health Network,Toronto,ON,Canada||Division of Thoracic Surgery,Department of Surgery,University Health Network,University of Toronto,Toronto Lung Transplant Program,Toronto,ON,Canada
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摘要

关键词

Pulmonary metastases/Colorectal cancer/Adjuvant chemotherapy/In vivo lung chemo-perfusion/Solid-phase microextraction(SPME)microprobes/Spatial metabolomics

Key words

Pulmonary metastases/Colorectal cancer/Adjuvant chemotherapy/In vivo lung chemo-perfusion/Solid-phase microextraction(SPME)microprobes/Spatial metabolomics

引用本文复制引用

Mariola Olkowicz,Khaled Ramadan,Hernando Rosales-Solano,Miao Yu,Aizhou Wang,Marcelo Cypel,Janusz Pawliszyn..Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics[J].药物分析学报（英文）,2024,14(2):196-210,15.

基金项目

This study was supported by the Canadian Institute of Health Research(CIHR)-Natural Sciences and Engineering Research Council(NSERC)of Canada Collaborative Health Research Projects program(Grant No.:355935),as well as by NSERC through the Industrial Research Chair(IRC)program(Program No.:#IRCPJ 184412e15).The funders had no role in the study design,data collection and analysis,decision to publish,or manuscript prepa-ration.We would also like to thank Supelco(Oakville,ON,Canada)for the MM and C18 SPME fibres,as well as the analytical columns that were used in this study. （CIHR）

药物分析学报（英文）

ISSN：2095-1779

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