Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomicsOA
Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics
Mariola Olkowicz;Khaled Ramadan;Hernando Rosales-Solano;Miao Yu;Aizhou Wang;Marcelo Cypel;Janusz Pawliszyn
Department of Chemistry,University of Waterloo,Waterloo,ON,Canada||Jagiellonian Centre for Experimental Therapeutics(JCET),Jagiellonian University,Krakow,PolandLamer Thoracic Surgery Research Laboratories,Toronto General Hospital Research Institute,University Health Network,Toronto,ON,CanadaDepartment of Chemistry,University of Waterloo,Waterloo,ON,CanadaThe Jackson Laboratory,JAX Genomic Medicine,Farmington,CT,USALamer Thoracic Surgery Research Laboratories,Toronto General Hospital Research Institute,University Health Network,Toronto,ON,CanadaLamer Thoracic Surgery Research Laboratories,Toronto General Hospital Research Institute,University Health Network,Toronto,ON,Canada||Division of Thoracic Surgery,Department of Surgery,University Health Network,University of Toronto,Toronto Lung Transplant Program,Toronto,ON,CanadaDepartment of Chemistry,University of Waterloo,Waterloo,ON,Canada
Pulmonary metastasesColorectal cancerAdjuvant chemotherapyIn vivo lung chemo-perfusionSolid-phase microextraction(SPME)microprobesSpatial metabolomics
Pulmonary metastasesColorectal cancerAdjuvant chemotherapyIn vivo lung chemo-perfusionSolid-phase microextraction(SPME)microprobesSpatial metabolomics
《药物分析学报（英文）》 2024 (2)
196-210,15
This study was supported by the Canadian Institute of Health Research(CIHR)-Natural Sciences and Engineering Research Council(NSERC)of Canada Collaborative Health Research Projects program(Grant No.:355935),as well as by NSERC through the Industrial Research Chair(IRC)program(Program No.:#IRCPJ 184412e15).The funders had no role in the study design,data collection and analysis,decision to publish,or manuscript prepa-ration.We would also like to thank Supelco(Oakville,ON,Canada)for the MM and C18 SPME fibres,as well as the analytical columns that were used in this study.
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