首页|期刊导航|药物分析学报（英文）|Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Ke-Gang Linghu Meiwan Chen Yuan-Jia Hu Chang-Sheng Zhang Hua Yu Tian Zhang Guang-Tao Zhang Peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao

药物分析学报（英文）2024，Vol.14Issue(3)：401-415,15.

药物分析学报（英文）2024，Vol.14Issue(3)：401-415,15.DOI:10.1016/j.jpha.2023.07.009

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

Ke-Gang Linghu ¹Meiwan Chen ²Yuan-Jia Hu ²Chang-Sheng Zhang ³Hua Yu ⁴Tian Zhang ²Guang-Tao Zhang ³Peng Lv ²Wen-Jun Zhang ³Guan-Ding Zhao ²Shi-Hang Xiong ²Qiu-Shuo Ma ²Ming-Ming Zhao²

作者信息

1. State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,China||State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang,550025,China
2. State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,China
3. Key Laboratory of Tropical Marine Bio-resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,RNAM Center for Marine Microbiology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou,510301,China
4. State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,China||Macao Centre for Research and Development in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,China
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摘要

关键词

Deoxynyboquinone/Anti-inflammation/Target/Keap1/Nrf2/Alkylation/Ubiquitination

Key words

Deoxynyboquinone/Anti-inflammation/Target/Keap1/Nrf2/Alkylation/Ubiquitination

引用本文复制引用

Ke-Gang Linghu,Meiwan Chen,Yuan-Jia Hu,Chang-Sheng Zhang,Hua Yu,Tian Zhang,Guang-Tao Zhang,Peng Lv,Wen-Jun Zhang,Guan-Ding Zhao,Shi-Hang Xiong,Qiu-Shuo Ma,Ming-Ming Zhao..Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy[J].药物分析学报（英文）,2024,14(3):401-415,15.

基金项目

This study was supported by the Science and Technology Development Fund,Macao SAR(Grant Nos.:No.0159/2020/A3,No.0058/2020/AMJ,No.0096/2019/A2 and SKL-QRCM(UM)-2023-2025),the Research Committee of the University of Macau(Grant No.:MYRG2022-00189-ICMS),the Guangdong Provincial Special Fund for Marine Economic Development Project(Project No.:GDNRC[2021]48),National Natural Science Foundation of China(Grant No.:82260801),and K.C.Wong Education Foundation(Grant No.:GJTD-2020-12).We greatly appreciate Ms.Parsa Dar for her language help. （Grant Nos.:No.0159/2020/A3,No.0058/2020/AMJ,No.0096/2019/A2 and SKL-QRCM(UM）

药物分析学报（英文）

ISSN：2095-1779

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