中国林副特产Issue(3)：31-34,4.DOI:10.13268/j.cnki.fbsic.2024.03.011
基于网络药理学探究黑涩楠果实对Ⅱ型糖尿病作用机制
Study on the Mechanism of Aronia melanocarpa Fruit Treating Diabetes Mellitus Type Ⅱ Based on Network Pharmacology
摘要
Abstract
To investigate the mechanism of action of Aronia melanocarpa Fruit on diabetes mellitus type Ⅱ using a network pharmacological approach.Methods:Venn analysis was performed by combining the Swiss Target Predic-tion database to obtain potential targets of action for AMF and the GeneCards database to obtain potential targets of action for T2DM.Build the"active ingredient-disease-target"network viewable diagram with Cytoscape 3.7.2 software.Establish Protein Interaction Network(PII)using the STRING 11.0 database.GO and KEGG pathway en-richment analysis of intersecting targets was performed through the DAVID 6.8 database.Results:A review of the literature yielded 19 AMF active ingredients,649 relevant targets,785 T2DM disease-related targets,and 82 inter-secting targets.KEGG pathway enrichment analysis was obtained for 103 pathways.The active ingredients and their mechanism of action of black chokeberry the treatment of diabetes mellitus type Ⅱ were predicted,providing a theo-retical basis for further research on Aronia melanocarpa Fruit the treatment of type Ⅱ diabetes.关键词
黑涩楠果实/Ⅱ型糖尿病/网络药理学Key words
Aronia melanocarpa Fruit/Diabetes mellitus type Ⅱ/Network pharmacology分类
农业科技引用本文复制引用
张春蕾,王丽红,杨丽,赵贺,文惠,袁全,周彤..基于网络药理学探究黑涩楠果实对Ⅱ型糖尿病作用机制[J].中国林副特产,2024,(3):31-34,4.基金项目
2022年黑龙江省大学生创新创业训练计划项目(S202210222145). （S202210222145）
