来曲唑诱导大鼠多囊卵巢综合征模型的肠道菌群分析OA北大核心CSTPCD
Gut microbiota in a rat model of polycystic ovary syndrome induced by letrozole
目的 探讨来曲唑(雌激素合成抑制剂)是否会对多囊卵巢综合征患者的肠道微生物群的组成、多样性和丰度有影响.方法 利用来曲唑诱导并构建了PCOS大鼠模型,通过 16S rRNA的测序方法分析了正常和PCOS大鼠模型的肠道菌群结构.结果 在门水平,PCOS组的厚壁菌门(73.29%±5.34%vs.77.17%±4.01%)的丰度较正常组降低,拟杆菌门(23.85%±6.22%vs.17.21%±6.90%)的丰度增加.在属水平,PCOS的罗氏菌属(5…查看全部>>
Objective To investigate the effects of the estrogen synthesis inhibitor letrozole on the composition,diversity,and abundance of the intestinal microbiota in rats with polycystic ovary syndrome(PCOS).Methods A rat model of PCOS was induced using the estrogen synthesis inhibitor letrozole.The gut microbiota structures of normal and PCOS rats were analyzed 16S rRNA sequencing.Results At the phylum level,rats in the PCOS group had a lower abundance of Firmicute…查看全部>>
杨宏;张振;付旭锋
宁夏医科大学生育力保持教育部重点实验室,银川 750004宁夏医科大学生育力保持教育部重点实验室,银川 750004宁夏医科大学生育力保持教育部重点实验室,银川 750004
生物学
多囊卵巢综合征肠道微生物16S rRNA测序厚壁菌门拟杆菌门胆汁酸生物合成
polycystic ovary syndromegut microbiota16S rRNA sequencingFirmicutesBacteroidetesbile acid biosynthesis
《中国实验动物学报》 2024 (5)
585-591,7
国家自然科学基金(81960270).Funded by National Natural Science Foundation of China(81960270).
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