小鼠血液中年龄相关的DNA甲基化微单倍型的筛选与验证OA北大核心CSTPCD
Screening and validation of age-related DNA methylation microhaplotypes in mouse blood
目的 DNA甲基化微单倍型是指极短范围内多个甲基化位点的组合,其单倍型具有丰富的多样性.筛选和验证小鼠血液中年龄相关的DNA甲基化微单倍型.方法 首先,构建基于小鼠参考基因组的DNA甲基化微单倍型理论数据集.其次,利用网络数据库中小鼠血液DNA甲基化高通量测序信息,采用Spearman秩相关分析方法筛选年龄相关的DNA甲基化微单倍型.最后,以验证数据集交叉验证.结果 小鼠基因组中 50 bp范围内的DNA甲基化微单倍型位点数量共计 6787 14…查看全部>>
Objective The DNA methylation microhaplotype(DMH)refers to the combination of multiple methylation sites within a very short range,and these haplotypes show wide diversity.We carried out screening and validation of age-related DMHs in mouse blood.Methods We initially constructed a theoretical dataset of DMHs based on the mouse reference genome.We then screened age-related DMHs by Spearman's rank correlation analysis,using high-throughput sequencing informati…查看全部>>
田艺博;吴雨静;肖君华;周宇荀;李凯
东华大学生物与医学工程学院,上海 201620东华大学生物与医学工程学院,上海 201620东华大学生物与医学工程学院,上海 201620东华大学生物与医学工程学院,上海 201620东华大学生物与医学工程学院,上海 201620
生物学
血液DNA甲基化微单倍型Spearman秩相关系数年龄筛选
bloodDNA methylation microhaplotypeSpearman's rank correlation coefficientagescreening
《中国实验动物学报》 2024 (5)
592-599,8
国家重点研发计划(2018YFA0801101).Funded by National Key Research and Development Program of China(2018YFA0801101).
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