中国实验动物学报2024，Vol.32Issue(5)：600-609,10.DOI:10.3969/j.issn.1005-4847.2024.05.007
智能针灸机器人针刺可行性及安全性评价实验动物平台建立的探索
Establishment of an experimental animal platform for evaluating the feasibility and safety of intelligent acupuncture robotic acupuncture
摘要
Abstract
Objective This study aimed to develop an experimental animal platform for evaluating the feasibility and safety of intelligent acupuncture robots and to lay the foundation for further research.Methods Six 2-month-old Guangxi Bama miniature pigs were used as experimental subjects for acupuncture verification after anesthesia.First,manual acupuncture verification was carried out.Six acupoints were selected for each experimental animal and the needles were left for 20 min after the lifting,inserting,and twisting manipulation.Before and after controls were included.The experiment was carried out for 28 days,and each experiment was conducted once every 2 days for a total of 10 times.After verification of manual acupuncture,a point 10 mm from each of the six selected acupoints was selected,with a total of 12 points,and acupuncture operations were carried out on the experimental animals using the intelligent acupuncture module of the acupuncture robot at different frequencies and angles,to further verify the stability and feasibility of the animal platform.Results Routine safety-related blood indicators and blood biochemistry indicators after the procedure were normal and stable compared with those before the procedure.The average heart rate of the animals was 124 beats/min,the average blood pressure was 87/36 mmHg,and the average body temperature of was 36℃at a room temperature of 25℃,with no significant change in body temperature during and after the experiment.On the basis of this experimental platform,acupuncture manipulation using the intelligent acupuncture module of the acupuncture robot was completed successfully,with no abnormalities related to acupuncture such as bending,breaking,or stagnation of needles during the experimental process,and the experimental animals showed no obvious abnormalities.Conclusions This study established a stable experimental animal platform for evaluating the feasibility and safety of acupuncture carried out by intelligent acupuncture robots,based on the existing experimental method of miniature pigs.These result lay a foundation for further research related to the use of intelligent acupuncture robots.关键词
智能针灸机器人/智能针刺模块/实验动物平台/巴马小型猪/安全性评价Key words
intelligent acupuncture robot/intelligent acupuncture module/experimental animal platform/Bama miniature pig/safety evaluation分类
生物科学引用本文复制引用
马唯刚,潘兴芳,邱继文,高卫芳,张永龙,董钰格,唐瑜紫,任海燕,李忠正..智能针灸机器人针刺可行性及安全性评价实验动物平台建立的探索[J].中国实验动物学报,2024,32(5):600-609,10.基金项目
国家重点研发计划项目(2022YFB4703104).Funded by National Key R&D Program Project(2022YFB4703104). （2022YFB4703104）
