没食子酸对脂多糖诱导的人THP1巨噬细胞炎症反应的抑制作用OA北大核心CSTPCD
Inhibition of lipopolysaccharide-induced inflammatory response by gallic acid in human THP1 macrophages
目的 探讨没食子酸(gallic acid,GA)对脂多糖(lipopolysaccharide,LPS)诱导的人THP1巨噬细胞炎症反应的抑制作用.方法 将人THP1单核细胞用佛波酯(phorbol myristate acetate,PMA)分化为巨噬细胞,用LPS诱导建立巨噬细胞炎症模型,给予不同浓度GA进行保护.CCK-8法筛选LPS和GA对THP1细胞的安全浓度;设正常组、模型组(100 μg/L LPS)和GA组(100 μg/L L…查看全部>>
Objective To investigate the inhibitory effect of gallic acid(GA)on lipopolysaccharide(LPS)-induced inflammatory responses in human THP1 macrophages.Methods THP1 monocytes were differentiated into macrophages with phorbol myristate acetate.A macrophage inflammation model was established with LPS induction,and GA was added at different concentrations.The safe concentrations of LPS and GA for THP1 cells were screened using the CCK-8 method,and a normal group,m…查看全部>>
刁佳雯;徐慧;马新月;全吉淑
延边大学医学院,吉林延吉 133002延边大学医学院,吉林延吉 133002延边大学医学院,吉林延吉 133002延边大学医学院,吉林延吉 133002
THP1细胞炎症没食子酸脂多糖
THP1 cellsinflammationgallic acidlipopolysaccharide
《中国比较医学杂志》 2024 (4)
41-53,13
国家自然科学地区科学基金项目(82060113).
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