中国比较医学杂志2024，Vol.34Issue(4)：100-108,9.DOI:10.3969/j.issn.1671-7856.2024.04.012
神经母细胞瘤肝及肾上腺移植模型比较
Comparison of liver and adrenal transplantation models of neuroblastoma
摘要
Abstract
Objective A neuroblastoma(NB)liver transplantation model was established and compared with the adrenal orthotopic transplantation model to explore its characteristics.Methods 5× 105 SK-N-SH cells were implanted along the long axis of the left lobe of mouse livers with a micro-injection needle.The growth,metastasis,expression of related genes,and histopathological changes of tumors were detected after the modeling.Results The tumor formation rate in mice inoculated with tumor cells reached 100％after 21 days,and tumor growth,metastasis,related gene expression changes,and pathological characteristics were apparent.Conclusions In this study,a neuroblastoma liver transplantation model was successfully constructed via a relatively simple surgical method to provide a more suitable choice for future scientific NB experiments.关键词
神经母细胞瘤/肾上腺原位移植/肝移植/疾病模型/成瘤率Key words
neuroblastoma/orthotopic adrenal transplantation/liver transplantation/disease model/rate of tumor formation分类
医药卫生引用本文复制引用
陈红霞,谭志刚,林惠然,冯露平,郑楚雅,廖文峰,曾如凤,刘锦信,卓振建..神经母细胞瘤肝及肾上腺移植模型比较[J].中国比较医学杂志,2024,34(4):100-108,9.基金项目
国家自然科学基金(82002636) （82002636）
深圳市自然科学基金(JCYJ20220531093213030). （JCYJ20220531093213030）
