中国比较医学杂志2024，Vol.34Issue(4)：114-122,128,10.DOI:10.3969/j.issn.1671-7856.2024.04.014
脑卒中神经环路研究技术进展
Technological advances in the study of post-stroke neural loops
摘要
Abstract
Neural loops are formed by interconnections between neurons through synaptic structures,which are the basic units of information transmission and processing in the brain and play an important role in the regulation of neural functions.After stroke,neural connections between the infarct and peri-infarct regions and the remote area are damaged,resulting in patients being at risk of neurological dysfunction or even disability.However,with advances in detection technology,an increasing number of studies are demonstrating that patients with stroke can undergo some functional recovery during the chronic phase,possibly via a mechanism related to the re-establishment of synaptic connections and neural circuits.Therefore,the development of specific technology to identify and manipulate neuronal activity patterns,as well as the use of high-resolution temporal and spatial imaging strategies to decipher these neurological processes,will allow us to understand the whole-brain network dynamics of stroke recovery and the mechanisms by which neural loop reestablishment occurs.Furthermore,we may be able to neurobiologically comprehend the closed-loop mechanisms that underlie the development of stroke pathology and their relationship to behavioral outcomes.Current technologies used for studying neural circuits include optogenetics,chemical genetics,in vivo calcium imaging,and functional magnetic resonance imaging.This article introduces the working principles of these four major technologies and focuses on summarizing the result of their respective application in resolving neural remodeling after stroke.We briefly analyze the application scenarios,advantages and disadvantages,and future development trends of each technique.This paper will help clinical and basic researchers to use these technologies to discover new therapeutic strategies and evaluate the effectiveness of rehabilitation strategies.关键词
卒中/神经环路/光遗传学/化学遗传学/成像技术Key words
stroke/neural loop/optogenetics/chemical genetics/imaging technology分类
医药卫生引用本文复制引用
陈彦熹,徐志栋,刘婷婷,马连素,孙芳玲,王文..脑卒中神经环路研究技术进展[J].中国比较医学杂志,2024,34(4):114-122,128,10.基金项目
国家自然科学基金面上项目(82173795) （82173795）
北京市自然科学基金(7242217). （7242217）
