中国比较医学杂志2024，Vol.34Issue(4)：129-138,10.DOI:10.3969/j.issn.1671-7856.2024.04.016
针刺调控缺血性卒中后铁死亡的作用机制研究进展
Progress in the study of mechanism of acupuncture in regulating ferroptosis after ischemic stroke
摘要
Abstract
Ischemic stroke(IS)presents a complex pathogenesis that poses numerous challenges in its treatment and rehabilitation.Acupuncture,a traditional Chinese medicine treatment,has garnered widespread attention for its effectiveness in treating IS,particularly its regulation of ferroptosis.Ferroptosis is a type of cell death dependent on iron and lipid peroxidation and is closely linked to neurological impairment following IS.This article reviews the primary mechanisms of ferroptosis post-IS,emphasizing the interconnections among iron metabolism,lipid peroxidation,mitochondrial damage,and ferroptosis.It further explores the mechanisms behind the ability of acupuncture to regulate ferroptosis after IS,including its roles in enhancing mitochondrial function,modulating iron metabolism,alleviating oxidative stress,suppressing inflammatory responses,and influencing various ferroptosis signaling pathways.This paper aims to provide a review of the scientific evidence and theoretical support for comprehensive therapeutic strategies for IS.关键词
针刺/缺血性卒中/铁死亡/铁/脂质过氧化Key words
acupuncture/ischemic stroke/ferroptosis/iron/lipid peroxidation分类
医药卫生引用本文复制引用
薛静,高莹,王舒..针刺调控缺血性卒中后铁死亡的作用机制研究进展[J].中国比较医学杂志,2024,34(4):129-138,10.基金项目
国家自然科学基金青年基金项目(82104998). （82104998）
