中国比较医学杂志2024，Vol.34Issue(4)：139-146,8.DOI:10.3969/j.issn.1671-7856.2024.04.017
NF-κB信号通路介导巨噬细胞参与心肌缺血再灌注损伤的研究进展
Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway
摘要
Abstract
Myocardial ischemia reperfusion injury(MIRI)has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases.The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI.Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages,pyrodeath,infiltration and other functions,and is a potential target for MIRI therapy.Therefore,this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.关键词
心肌缺血再灌注损伤/巨噬细胞/NF-κB通路Key words
myocardial ischemia reperfusion injury/macrophage/NF-κB pathway分类
医药卫生引用本文复制引用
李世龙,王贺,曹英杰..NF-κB信号通路介导巨噬细胞参与心肌缺血再灌注损伤的研究进展[J].中国比较医学杂志,2024,34(4):139-146,8.基金项目
国家自然科学基金(82274316) （82274316）
河南省中医药科学研究专项课题(2019JDZX2071,2022JDZX037). （2019JDZX2071,2022JDZX037）
