中国比较医学杂志2024，Vol.34Issue(4)：156-164,9.DOI:10.3969/j.issn.1671-7856.2024.04.019
糖代谢重编程在阿尔茨海默病发病机制中的研究进展
Advances in the study of glucose metabolic reprogramming in the pathogenesis of Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by widespread dementia.Despite the extensive research conducted on the pathogenesis of AD over the past 50 years,the underlying mechanisms responsible for AD-related cellular damage and cognitive impairment remain elusive.Multiple studies have confirmed alterations in the glucose metabolism patterns occur within the nerve cells of individuals with AD.This metabolic transition plays a crucial role in cell survival and disease progression,occurring decades before pathological changes and cognitive dysfunction even manifest.This article provides an overview of the potential mechanisms through which glucose metabolism reprogramming contributes to AD development in various types of nerve cells and brain regions,as well as the implication of their interplay.We aim to establish a foundation for further investigations into AD while offering insights and ideas for the development of novel preventive and therapeutic approaches.关键词
阿尔茨海默病/神经细胞/葡萄糖代谢重编程/研究进展Key words
Alzheimer's disease/nerve cells/glucose metabolic reprogramming/research progress分类
医药卫生引用本文复制引用
许倩,杨琼,谭子虎..糖代谢重编程在阿尔茨海默病发病机制中的研究进展[J].中国比较医学杂志,2024,34(4):156-164,9.基金项目
湖北省自然科学基金联合基金重点项目(2022CFD022) （2022CFD022）
湖北省自然科学基金联合基金青年项目(2022CFD143,2022CDF144). （2022CFD143,2022CDF144）
